MAD homolog 7 (Drosophila)

Synonym

SMAD 7, Smad7, Mothers against DPP homolog 7, Mothers against decapentaplegic homolog 7, MAD homolog 7 (Drosophila), Madh7, Madh8

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:6.90

cerebellum:36.80

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:64.30

eye:7.60

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:12.50

skin:7.90

GeneChip

cerebrum:7.80

cerebellum:7.68

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:6.60

spine:8.71

retina:7.28

eye:7.27

artery/aorta:-

vein:7.87

lymphnode:8.27

peripheral blood:-

spleen:8.29

thymus:-

bone marrow:6.78

adipose:7.13

bone:7.07

skin:6.66

CAGE

cerebrum:3.30

cerebellum:-

brain stem:3.73

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:4.06

retina:-

eye:-

artery/aorta:3.45

vein:-

lymphnode:3.30

peripheral blood:-

spleen:2.61

thymus:2.29

bone marrow:-

adipose:-

bone:2.97

skin:3.74

RNA-seq

cerebrum:1.63

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:43.60

placenta:41.40

prostate:30.90

ovary:11.50

testis:236.50

heart:37.20

muscle:-

esophagus:-

stomach:32.70

intestine:-

colon:17.60

liver/hepato:-

lung:30.10

bladder:66.20

kidney:24.20

pituitary:374.60

thyroid/parathyroid:-

adrenal gland:-

pancreas:197

breast:13.10

salivary:-

GeneChip

uterus:7.61

placenta:8.72

prostate:7.50

ovary:7.58

testis:6.49

heart:8.04

muscle:7.33

esophagus:-

stomach:8.34

intestine:8.46

colon:-

liver/hepato:7.19

lung:9.49

bladder:7.88

kidney:7.93

pituitary:7.43

thyroid/parathyroid:-

adrenal gland:7.25

pancreas:6.92

breast:7.35

salivary:6.87

CAGE

uterus:3.66

placenta:4.38

prostate:3.80

ovary:3.22

testis:0.99

heart:-

muscle:-

esophagus:-

stomach:3.98

intestine:3.70

colon:4.34

liver/hepato:3.45

lung:4.49

bladder:3.48

kidney:-

pituitary:2.89

thyroid/parathyroid:-

adrenal gland:3.30

pancreas:3.83

breast:3.00

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:1.58

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:2.89

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_001042660
Gene ID	17131
Unigene ID	Mm.344071
Probe set ID	1423389_at [Mouse430_2]
Ensembl ID	ENSMUSG00000025880

Orthologous Gene

Human[1]	NM_001190821, NM_001190822, NM_001190823, NM_005904
Rat[1]	NM_030858, NM_001190822, NM_001190823, NM_005904

Chromosomal Region

Gene Family (Interpro ID)

IPR003619	MAD homology 1, Dwarfin-type
IPR013019	MAD homology, MH1
IPR001132	SMAD domain, Dwarfin-type
IPR017855	SMAD domain-like
IPR008984	SMAD/FHA domain

Gene Ontology (GO ID)

Biological Process

GO:0034333	adherens junction assembly
GO:0048844	artery morphogenesis
GO:0034629	cellular protein complex localization
GO:0030514	negative regulation of BMP signaling pathway
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0031397	negative regulation of protein ubiquitination
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0043433	negative regulation of transcription factor activity
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0051444	negative regulation of ubiquitin-protein ligase activity
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:0022409	positive regulation of cell-cell adhesion
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398	positive regulation of protein ubiquitination
GO:0050821	protein stabilization
GO:0032925	regulation of activin receptor signaling pathway
GO:0055117	regulation of cardiac muscle contraction
GO:0006355	regulation of transcription, DNA-dependent
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0060373	regulation of ventricular cardiomyocyte membrane depolarization
GO:0006351	transcription, DNA-dependent
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060412	ventricular septum morphogenesis

Cellular Component

GO:0016342	catenin complex
GO:0005913	cell-cell adherens junction
GO:0005737	cytoplasm
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0043234	protein complex
GO:0005667	transcription factor complex

Molecular Function

GO:0048185	activin binding
GO:0008013	beta-catenin binding
GO:0005518	collagen binding
GO:0003677	DNA binding
GO:0044212	DNA regulatory region binding
GO:0070411	I-SMAD binding
GO:0046872	metal ion binding
GO:0005515	protein binding
GO:0003700	transcription factor activity
GO:0030617	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0034713	type I transforming growth factor beta receptor binding
GO:0031625	ubiquitin protein ligase binding

MAD homolog 7 (Drosophila)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function