p21 protein (Cdc42/Rac)-activated kinase 1

Synonym

PAK-1, Paka, AW045634, Alpha-PAK, p21 (CDKN1A)-activated kinase 1, Pak1, Serine/threonine-protein kinase PAK 1, P65-PAK, p21-activated kinase 1, CDC42/RAC effector kinase PAK-A

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:118.10

cerebellum:73.70

brain stem:63.60

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:94.60

retina:-

eye:53.20

artery/aorta:168.80

vein:-

lymphnode:-

peripheral blood:14.40

spleen:-

thymus:29.60

bone marrow:12.80

adipose:-

bone:25

skin:7.90

GeneChip

cerebrum:10.84

cerebellum:11.43

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:9.21

spine:11.19

retina:6.87

eye:6.89

artery/aorta:-

vein:7.36

lymphnode:7.41

peripheral blood:-

spleen:7.40

thymus:-

bone marrow:7.45

adipose:6.47

bone:7.68

skin:7.49

CAGE

cerebrum:5.60

cerebellum:-

brain stem:5.60

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:5.69

retina:-

eye:-

artery/aorta:1.70

vein:-

lymphnode:3.77

peripheral blood:-

spleen:2.89

thymus:3.13

bone marrow:-

adipose:-

bone:3.54

skin:3.65

RNA-seq

cerebrum:54.25

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:43.60

placenta:27.60

prostate:-

ovary:80.40

testis:7.40

heart:-

muscle:177.50

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:-

bladder:-

kidney:32.20

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:26.10

salivary:-

GeneChip

uterus:7.59

placenta:7.27

prostate:6.92

ovary:6.43

testis:6.24

heart:6

muscle:8.39

esophagus:-

stomach:8.17

intestine:8.91

colon:-

liver/hepato:5.76

lung:6.97

bladder:7.21

kidney:8.48

pituitary:9.25

thyroid/parathyroid:-

adrenal gland:7.07

pancreas:7.64

breast:7.37

salivary:6.71

CAGE

uterus:3.28

placenta:2.58

prostate:3.90

ovary:2.63

testis:3.03

heart:-

muscle:-

esophagus:-

stomach:3.51

intestine:3.64

colon:4.12

liver/hepato:2.26

lung:2.95

bladder:3.12

kidney:-

pituitary:4.25

thyroid/parathyroid:-

adrenal gland:3.28

pancreas:2.03

breast:2.69

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:4.77

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:1.50

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_011035
Gene ID	18479
Unigene ID	Mm.260227
Probe set ID	1420980_at [Mouse430_2]
Ensembl ID	ENSMUSG00000030774

Orthologous Gene

Human[2]	NM_001128620, NM_002576
Rat [0]

Chromosomal Region

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0031532	actin cytoskeleton reorganization
GO:0006915	apoptosis
GO:0048754	branching morphogenesis of a tube
GO:0032869	cellular response to insulin stimulus
GO:0033554	cellular response to stress
GO:0016358	dendrite development
GO:0006887	exocytosis
GO:0008152	metabolic process
GO:0060244	negative regulation of cell proliferation involved in contact inhibition
GO:0007528	neuromuscular junction development
GO:0048812	neuron projection morphogenesis
GO:0016310	phosphorylation
GO:0033148	positive regulation of estrogen receptor signaling pathway
GO:0043507	positive regulation of JUN kinase activity
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0051496	positive regulation of stress fiber formation
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0043113	receptor clustering
GO:0032956	regulation of actin cytoskeleton organization
GO:0001666	response to hypoxia
GO:0010033	response to organic substance
GO:0042060	wound healing

Cellular Component

GO:0030424	axon
GO:0030054	cell junction
GO:0005911	cell-cell junction
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030425	dendrite
GO:0005925	focal adhesion
GO:0005794	Golgi apparatus
GO:0030426	growth cone
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0043234	protein complex
GO:0001726	ruffle
GO:0030018	Z disc

Molecular Function

GO:0005524	ATP binding
GO:0003824	catalytic activity
GO:0005518	collagen binding
GO:0042802	identical protein binding
GO:0016301	kinase activity
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0019901	protein kinase binding
GO:0004674	protein serine/threonine kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

p21 protein (Cdc42/Rac)-activated kinase 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function