peptidylglycine alpha-amidating monooxygenase

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Synonym

PAM, Pam, peptidylglycine alpha-amidating monooxygenase

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:3.50 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:5.41 cerebellum:3.46 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.76 spine:4.80 retina:4.69 eye:5.57 artery/aorta:- vein:5.82 lymphnode:4 peripheral blood:- spleen:4.02 thymus:- bone marrow:3.87 adipose:4.81 bone:4.47 skin:4.99
CAGE cerebrum:3.89 cerebellum:- brain stem:4.48 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.55 retina:- eye:- artery/aorta:5.43 vein:- lymphnode:3.66 peripheral blood:- spleen:3.14 thymus:2.99 bone marrow:- adipose:- bone:3.83 skin:4.23
RNA-seq cerebrum:11.79 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:35.50 esophagus:- stomach:65.50 intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.95 placenta:6.07 prostate:6.18 ovary:4.97 testis:3.68 heart:6.56 muscle:4.64 esophagus:- stomach:4.62 intestine:4.88 colon:- liver/hepato:4.01 lung:6.08 bladder:5.79 kidney:5.16 pituitary:6.88 thyroid/parathyroid:- adrenal gland:5.78 pancreas:5.45 breast:4.83 salivary:5.21
CAGE uterus:4.70 placenta:5.22 prostate:3.99 ovary:4.36 testis:1.48 heart:- muscle:- esophagus:- stomach:3.92 intestine:3.48 colon:3.84     liver/hepato:3.59    lung:5.34 bladder:5.30 kidney:- pituitary:6.06 thyroid/parathyroid:- adrenal gland:5.35 pancreas:4.61 breast:3.67 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:3.60 esophagus:- stomach:- intestine:- colon:-     liver/hepato:3.19        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_013626
Gene ID 18484
Unigene ID Mm.441453
Probe set ID 1418908_at  [Mouse430_2]
Ensembl ID ENSMUSG00000026335

Orthologous Gene

Human[8]  NM_000919, NM_001177306, NM_138766, NM_138821, NM_138822
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR001258  NHL repeat
IPR013017  NHL repeat, subgroup

Link to Pubmed  (Pubmed ID)

1448112
7873888
8672144
8910496
8938438
10219055
10349636
11028916
11042159
11076861
11217851
12466851
12477932
12748967
15629125
15745951
16141072
16141073
16225857
16325307
16465591
17005911
18554416
19554387
19815072
19954489
20534529
20573687
20648645
20943906
21267068
21677750
21873192
22194882
24032518

Gene Ontology  (GO ID)

Biological Process

GO:0001676  long-chain fatty acid metabolic process
GO:0008152  metabolic process
GO:0055114  oxidation reduction
GO:0001519  peptide amidation
GO:0006518  peptide metabolic process
GO:0018032  protein amino acid amidation
GO:0051260  protein homooligomerization
GO:0019538  protein metabolic process
GO:0032956  regulation of actin cytoskeleton organization
GO:0050708  regulation of protein secretion
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0042493  response to drug
GO:0009268  response to pH
GO:0009404  toxin metabolic process

Cellular Component

GO:0043025  cell soma
GO:0009986  cell surface
GO:0031410  cytoplasmic vesicle
GO:0005829  cytosol
GO:0005615  extracellular space
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0043005  neuron projection
GO:0043204  perikaryon
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0030141  secretory granule
GO:0030667  secretory granule membrane
GO:0005802  trans-Golgi network

Molecular Function

GO:0005509  calcium ion binding
GO:0003824  catalytic activity
GO:0005507  copper ion binding
GO:0031418  L-ascorbic acid binding
GO:0016829  lyase activity
GO:0046872  metal ion binding
GO:0004497  monooxygenase activity
GO:0016491  oxidoreductase activity
GO:0016715  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
GO:0004598  peptidylamidoglycolate lyase activity
GO:0004504  peptidylglycine monooxygenase activity
GO:0019901  protein kinase binding
GO:0008270  zinc ion binding