furin (paired basic amino acid cleaving enzyme)

Synonym

Paired basic amino acid residue cleaving enzyme, Prohormone convertase 3, PACE, Pcsk3, Dibasic-processing enzyme, Furin, Furin precursor, Fur, SPC1, furin (paired basic amino acid cleaving enzyme)

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:10.40

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:19.10

spine:94.60

retina:32.10

eye:60.80

artery/aorta:-

vein:-

lymphnode:345.60

peripheral blood:43.10

spleen:65.80

thymus:69.20

bone marrow:128.20

adipose:-

bone:112.70

skin:15.80

GeneChip

cerebrum:6.32

cerebellum:6.42

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:6.77

spine:6.15

retina:7.37

eye:7.55

artery/aorta:-

vein:7.11

lymphnode:6.93

peripheral blood:-

spleen:6.94

thymus:-

bone marrow:7.44

adipose:7.63

bone:7.13

skin:7.16

CAGE

cerebrum:3.05

cerebellum:-

brain stem:2.61

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:2.79

retina:-

eye:-

artery/aorta:4.25

vein:-

lymphnode:3.07

peripheral blood:-

spleen:3.58

thymus:2.96

bone marrow:-

adipose:-

bone:3.62

skin:4.46

RNA-seq

cerebrum:4.55

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:43.60

placenta:303.80

prostate:-

ovary:34.50

testis:-

heart:55.80

muscle:35.50

esophagus:-

stomach:98.20

intestine:-

colon:123.40

liver/hepato:99.60

lung:80.30

bladder:132.40

kidney:64.50

pituitary:12.90

thyroid/parathyroid:-

adrenal gland:-

pancreas:46.90

breast:71.80

salivary:162

GeneChip

uterus:7.69

placenta:8.31

prostate:7.61

ovary:8.07

testis:6.32

heart:7.63

muscle:7.60

esophagus:-

stomach:9.91

intestine:7.34

colon:-

liver/hepato:8.94

lung:7.78

bladder:7.51

kidney:8.53

pituitary:7.05

thyroid/parathyroid:-

adrenal gland:8.39

pancreas:8.29

breast:7.45

salivary:8.03

CAGE

uterus:4.37

placenta:4.61

prostate:3.97

ovary:3.96

testis:1.89

heart:-

muscle:-

esophagus:-

stomach:6.51

intestine:4.77

colon:4.36

liver/hepato:4.92

lung:4.32

bladder:4.01

kidney:-

pituitary:3.45

thyroid/parathyroid:-

adrenal gland:4.62

pancreas:5.27

breast:4.71

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:3.55

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:15.45

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_001081454
Gene ID	18550
Unigene ID	Mm.5241
Probe set ID	1418518_at [Mouse430_2]
Ensembl ID	ENSMUSG00000030530

Orthologous Gene

Human[1]	NM_002569
Rat [0]

Chromosomal Region

Gene Family (Interpro ID)

IPR015500	Peptidase S8, subtilisin-related
IPR000209	Peptidase S8/S53, subtilisin/kexin/sedolisin

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

GO:0008283	cell proliferation
GO:0032804	negative regulation of low-density lipoprotein receptor catabolic process
GO:0032911	negative regulation of transforming growth factor-beta1 production
GO:0032902	nerve growth factor production
GO:0043043	peptide biosynthetic process
GO:0016486	peptide hormone processing
GO:0030335	positive regulation of cell migration
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0016485	protein processing
GO:0006508	proteolysis
GO:0052548	regulation of endopeptidase activity
GO:0042176	regulation of protein catabolic process
GO:0009966	regulation of signal transduction
GO:0032940	secretion by cell
GO:0006465	signal peptide processing

Cellular Component

GO:0009986	cell surface
GO:0005769	early endosome
GO:0005789	endoplasmic reticulum membrane
GO:0005615	extracellular space
GO:0005794	Golgi apparatus
GO:0031985	Golgi cisterna
GO:0016021	integral to membrane
GO:0016020	membrane
GO:0045121	membrane raft
GO:0005886	plasma membrane
GO:0005802	trans-Golgi network
GO:0030140	trans-Golgi network transport vesicle
GO:0012510	trans-Golgi network transport vesicle membrane

Molecular Function

GO:0004175	endopeptidase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding
GO:0048406	nerve growth factor binding
GO:0008233	peptidase activity
GO:0042277	peptide binding
GO:0002020	protease binding
GO:0005515	protein binding
GO:0004252	serine-type endopeptidase activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0008236	serine-type peptidase activity

furin (paired basic amino acid cleaving enzyme)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function