phosphodiesterase 1C

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Synonym

phosphodiesterase 1C, Cam-PDE 1C, Pde1c

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:10.40 cerebellum:405.30 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:22.80 artery/aorta:- vein:- lymphnode:- peripheral blood:14.40 spleen:- thymus:19.80 bone marrow:- adipose:- bone:- skin:7.90
GeneChip cerebrum:4.40 cerebellum:6.85 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.49 spine:4.39 retina:5.10 eye:4.78 artery/aorta:- vein:4.06 lymphnode:4.26 peripheral blood:- spleen:4.44 thymus:- bone marrow:4.30 adipose:4.23 bone:4.37 skin:4.78
CAGE cerebrum:2.29 cerebellum:- brain stem:1.84 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.11 retina:- eye:- artery/aorta:0.14 vein:- lymphnode:0.83 peripheral blood:- spleen:0 thymus:1.06 bone marrow:- adipose:- bone:0 skin:0.15
RNA-seq cerebrum:1.75 cerebellum:1.75 brain stem:1.75 corpus callosum/glia:1.75 pineal gland:1.75 peripheral nerve:1.75 spine:1.75 retina:1.75 eye:1.75 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:23 testis:229.10 heart:74.40 muscle:- esophagus:- stomach:32.70 intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:64.60 thyroid/parathyroid:- adrenal gland:- pancreas:46.90 breast:- salivary:108
GeneChip uterus:4.08 placenta:4.24 prostate:4 ovary:3.89 testis:8.30 heart:5.54 muscle:4.52 esophagus:- stomach:4.71 intestine:4.26 colon:- liver/hepato:4.24 lung:4.09 bladder:4.28 kidney:4.27 pituitary:4.98 thyroid/parathyroid:- adrenal gland:4.28 pancreas:4.79 breast:4.14 salivary:4.54
CAGE uterus:0.55 placenta:0.36 prostate:0 ovary:0.13 testis:5.64 heart:- muscle:- esophagus:- stomach:2.04 intestine:0.72 colon:0.41     liver/hepato:0    lung:0.31 bladder:0 kidney:- pituitary:2.56 thyroid/parathyroid:- adrenal gland:0 pancreas:0 breast:0.32 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001025568
Gene ID 18575
Unigene ID Mm.5145
Probe set ID 1429643_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000004347

Orthologous Gene

Human[1]  NM_001191056, NM_001191057, NM_001191058, NM_001191059, NM_005020
Rat [0]  

Chromosomal Region

6B3  [56,019,815  -  56,319,628]

Gene Family (Interpro ID)

IPR003607  Metal-dependent phosphohydrolase, HD domain

Link to Pubmed  (Pubmed ID)

7568196
8810348
8889548
9003415
10349636
11042159
11076861
11217851
12466851
12477932
14586460
14681479
16141072
16141073
16602821
17307970
17953485
18554416
19305400
19741056
20705924
21491433
21677750

Gene Ontology  (GO ID)

Biological Process

GO:0006198  cAMP catabolic process
GO:0046069  cGMP catabolic process
GO:0046676  negative regulation of insulin secretion
GO:0051592  response to calcium ion
GO:0007608  sensory perception of smell
GO:0007165  signal transduction

Cellular Component

GO:0043025  cell soma
GO:0005929  cilium

Molecular Function

GO:0004115  3',5'-cyclic-AMP phosphodiesterase activity
GO:0004114  3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0048101  calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
GO:0005516  calmodulin binding
GO:0004117  calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0030552  cAMP binding
GO:0003824  catalytic activity
GO:0016787  hydrolase activity
GO:0046872  metal ion binding
GO:0008081  phosphoric diester hydrolase activity