phospholipase C, beta 1

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Synonym

mKIAA0581, Plcb, PLC-154, PLC-beta-1, Phospholipase C-beta-1, AI132408, PLC-I, 3110043I21Rik, Plcb1, phospholipase C, beta 1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:132 cerebellum:73.70 brain stem:95.30 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:189.10 retina:- eye:22.80 artery/aorta:506.30 vein:- lymphnode:75.60 peripheral blood:- spleen:- thymus:- bone marrow:12.80 adipose:- bone:25 skin:15.80
GeneChip cerebrum:7.10 cerebellum:5.83 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.76 spine:6.03 retina:5.47 eye:5.56 artery/aorta:- vein:5.41 lymphnode:5.54 peripheral blood:- spleen:5.29 thymus:- bone marrow:5.48 adipose:5.69 bone:5.39 skin:5.36
CAGE cerebrum:4.75 cerebellum:- brain stem:4.39 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.36 retina:- eye:- artery/aorta:3.40 vein:- lymphnode:2.41 peripheral blood:- spleen:1.63 thymus:0.67 bone marrow:- adipose:- bone:1.97 skin:2.54
RNA-seq cerebrum:6.41 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:92.60 ovary:11.50 testis:7.40 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:9.10        lung:-    bladder:- kidney:16.10 pituitary:12.90 thyroid/parathyroid:- adrenal gland:848.90 pancreas:- breast:35.90 salivary:-
GeneChip uterus:5.15 placenta:5.45 prostate:5.21 ovary:5.15 testis:5.50 heart:5.60 muscle:5.45 esophagus:- stomach:5.45 intestine:5.40 colon:- liver/hepato:5.29 lung:5.46 bladder:5.45 kidney:5.87 pituitary:5.71 thyroid/parathyroid:- adrenal gland:5.98 pancreas:6.16 breast:5.42 salivary:5.85
CAGE uterus:2.50 placenta:1.20 prostate:2.33 ovary:3.31 testis:1.97 heart:- muscle:- esophagus:- stomach:1.91 intestine:2.43 colon:2.71     liver/hepato:3.85    lung:3.75 bladder:2.73 kidney:- pituitary:3.56 thyroid/parathyroid:- adrenal gland:5.19 pancreas:4.30 breast:3.11 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.02 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.41        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001145830
Gene ID 18795
Unigene ID Mm.330607
Probe set ID 1421170_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000051177

Orthologous Gene

Human[6]  NM_015192, NM_182734
Rat[1]  NM_001077641, NM_182734

Chromosomal Region

2F3  [134,611,895  -  135,300,994]

Gene Family (Interpro ID)

IPR000008  C2 calcium-dependent membrane targeting
IPR008973  C2 calcium/lipid-binding domain, CaLB
IPR018029  C2 membrane targeting protein

Link to Pubmed  (Pubmed ID)

2033248
7642703
7916325
8617512
8672127
8687404
8739298
8889548
9159640
9187110
9305844
9444325
9753089
9762362
10349636
10609087
10913438
11042159
11076861
11217851
11224545
11464583
11471062
11487662
12031797
12123715
12364493
12466851
12477932
12860966
14499343
14621295
14681479
15174099
15474310
15572359
15664177
15702972
15749982
15849202
15864321
16141072
16141073
16210321
16330775
16339037
16405873
16538662
16602821
16951552
17022104
17114649
17620288
17634444
17667964
17696993
17725492
17925404
17961538
18287559
18493969
18690108
18692062
18799693
18836131
18957514
18973591
19028838
19159640
19236734
19342451
19385066
19687358
19729020
19850892
20392936
21677750
21974932
22103416
22171034
23295235
23478264
23665500
24227722

Gene Ontology  (GO ID)

Biological Process

GO:0060466  activation of meiosis involved in egg activation
GO:0007420  brain development
GO:0007155  cell adhesion
GO:0021987  cerebral cortex development
GO:0030218  erythrocyte differentiation
GO:0045444  fat cell differentiation
GO:0000086  G2/M transition of mitotic cell cycle
GO:0007215  glutamate signaling pathway
GO:0008286  insulin receptor signaling pathway
GO:0048009  insulin-like growth factor receptor signaling pathway
GO:0070498  interleukin-1-mediated signaling pathway
GO:0016042  lipid catabolic process
GO:0006629  lipid metabolic process
GO:0030225  macrophage differentiation
GO:0007613  memory
GO:0006397  mRNA processing
GO:0007213  muscarinic acetylcholine receptor signaling pathway
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0001556  oocyte maturation
GO:0048639  positive regulation of developmental growth
GO:0040019  positive regulation of embryonic development
GO:0043547  positive regulation of GTPase activity
GO:0032735  positive regulation of interleukin-12 production
GO:0046330  positive regulation of JNK cascade
GO:0045663  positive regulation of myoblast differentiation
GO:0032417  positive regulation of sodium:hydrogen antiporter activity
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0008277  regulation of G-protein coupled receptor protein signaling pathway
GO:0034284  response to monosaccharide stimulus
GO:0043434  response to peptide hormone stimulus
GO:0007165  signal transduction

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0016020  membrane
GO:0000790  nuclear chromatin
GO:0016607  nuclear speck
GO:0005634  nucleus

Molecular Function

GO:0005509  calcium ion binding
GO:0005516  calmodulin binding
GO:0019899  enzyme binding
GO:0005096  GTPase activator activity
GO:0016787  hydrolase activity
GO:0005521  lamin binding
GO:0005546  phosphatidylinositol-4,5-bisphosphate binding
GO:0004435  phosphoinositide phospholipase C activity
GO:0008081  phosphoric diester hydrolase activity
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0004871  signal transducer activity