inositol polyphosphate 5-phosphatase K

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Synonym

Pps, putative phosphatase, PI-5-phosphatase related, Skip, RP23-136K12.4, putative PI-5-phosphatase, C62

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:8.39 cerebellum:8.84 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:9.29 spine:8.30 retina:10.56 eye:8.55 artery/aorta:- vein:8.19 lymphnode:9.39 peripheral blood:- spleen:9.28 thymus:- bone marrow:9.18 adipose:8.68 bone:9.06 skin:9.02
CAGE cerebrum:3.79 cerebellum:- brain stem:3.52 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.55 retina:- eye:- artery/aorta:3.81 vein:- lymphnode:4.24 peripheral blood:- spleen:3.44 thymus:4.05 bone marrow:- adipose:- bone:3.85 skin:3.37
RNA-seq cerebrum:6.82 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:9.06 placenta:8.43 prostate:9.22 ovary:8.48 testis:9.49 heart:8.33 muscle:8.49 esophagus:- stomach:8.21 intestine:8.31 colon:- liver/hepato:7.23 lung:9.49 bladder:8.68 kidney:8.50 pituitary:8.53 thyroid/parathyroid:- adrenal gland:8.88 pancreas:8.17 breast:9.07 salivary:8.98
CAGE uterus:3.30 placenta:3.43 prostate:3.73 ovary:3.34 testis:5.78 heart:- muscle:- esophagus:- stomach:3.51 intestine:2.64 colon:3.02     liver/hepato:2.90    lung:4.41 bladder:3.49 kidney:- pituitary:3.59 thyroid/parathyroid:- adrenal gland:3.75 pancreas:3.04 breast:4.25 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:7.25 esophagus:- stomach:- intestine:- colon:-     liver/hepato:3.66        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_008916
Gene ID 19062
Unigene ID -
Probe set ID 1416195_at  [Mouse430_2]
Ensembl ID ENSMUSG00000006127

Orthologous Gene

Human[6]  NM_001135642, NM_016532, NM_130766
Rat[6]  NM_001135642, NM_016532, NM_130766

Chromosomal Region

-

Gene Family (Interpro ID)

IPR005135  Endonuclease/exonuclease/phosphatase
IPR000300  Inositol polyphosphate related phosphatase

Link to Pubmed  (Pubmed ID)

7237550
9182797
10325425
10349636
10922068
11042159
11076861
11217851
11471062
12466851
12477932
12536145
14610273
14681479
15489334
16141072
16141073
18573875
18799693
19250614
19801640
21267068
21677750
21712384
21938401
22247557
22751929
22815484

Gene Ontology  (GO ID)

Biological Process

GO:0071320  cellular response to cAMP
GO:0071364  cellular response to epidermal growth factor stimulus
GO:0032870  cellular response to hormone stimulus
GO:0032869  cellular response to insulin stimulus
GO:0071356  cellular response to tumor necrosis factor
GO:0016311  dephosphorylation
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0042593  glucose homeostasis
GO:0001701  in utero embryonic development
GO:0046855  inositol phosphate dephosphorylation
GO:0043922  negative regulation by host of viral transcription
GO:0051926  negative regulation of calcium ion transport
GO:0035305  negative regulation of dephosphorylation
GO:0010829  negative regulation of glucose transport
GO:0045719  negative regulation of glycogen biosynthetic process
GO:0046627  negative regulation of insulin receptor signaling pathway
GO:0043407  negative regulation of MAP kinase activity
GO:0033137  negative regulation of peptidyl-serine phosphorylation
GO:0010801  negative regulation of peptidyl-threonine phosphorylation
GO:0001933  negative regulation of protein amino acid phosphorylation
GO:0006469  negative regulation of protein kinase activity
GO:0051898  negative regulation of protein kinase B signaling cascade
GO:0045869  negative regulation of retroviral genome replication
GO:0051497  negative regulation of stress fiber formation
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0046856  phosphoinositide dephosphorylation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0005979  regulation of glycogen biosynthetic process
GO:0032868  response to insulin stimulus

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005783  endoplasmic reticulum
GO:0016020  membrane
GO:0043005  neuron projection
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0001726  ruffle
GO:0032587  ruffle membrane
GO:0005802  trans-Golgi network

Molecular Function

GO:0016787  hydrolase activity
GO:0016312  inositol bisphosphate phosphatase activity
GO:0046030  inositol trisphosphate phosphatase activity
GO:0004445  inositol-polyphosphate 5-phosphatase activity
GO:0034594  phosphatidylinositol trisphosphate phosphatase activity
GO:0034485  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0034595  phosphoinositide 5-phosphatase activity
GO:0005000  vasopressin receptor activity