prostaglandin E receptor 4 (subtype EP4)

Synonym

Prostaglandin E2 receptor, EP4 subtype, prostaglandin E receptor 4 (subtype EP4), EP4, PGE receptor, EP4 subtype, Ptgerep4, Prostanoid EP4 receptor, Ptger4

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:12.20

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:38.20

spine:-

retina:-

eye:-

artery/aorta:84.40

vein:-

lymphnode:21.60

peripheral blood:86.30

spleen:250.20

thymus:138.30

bone marrow:25.60

adipose:-

bone:37.60

skin:39.60

GeneChip

cerebrum:4.87

cerebellum:4.35

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:7.45

spine:6.14

retina:5.29

eye:6.14

artery/aorta:-

vein:6.80

lymphnode:9.86

peripheral blood:-

spleen:8.60

thymus:-

bone marrow:8.34

adipose:7.22

bone:8.38

skin:9.32

CAGE

cerebrum:0.22

cerebellum:-

brain stem:0.51

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:0.83

retina:-

eye:-

artery/aorta:2.38

vein:-

lymphnode:4.11

peripheral blood:-

spleen:3.14

thymus:3.72

bone marrow:-

adipose:-

bone:3.02

skin:3.77

RNA-seq

cerebrum:1.00

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:87.20

placenta:27.60

prostate:-

ovary:23

testis:7.40

heart:-

muscle:71

esophagus:-

stomach:-

intestine:110.90

colon:70.50

liver/hepato:54.30

lung:10

bladder:132.40

kidney:8.10

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:97.90

salivary:-

GeneChip

uterus:9.85

placenta:6.11

prostate:5.75

ovary:8.17

testis:4.18

heart:6.09

muscle:6.14

esophagus:-

stomach:8.40

intestine:9.86

colon:-

liver/hepato:4.58

lung:6.49

bladder:7.64

kidney:5.77

pituitary:4.74

thyroid/parathyroid:-

adrenal gland:5.66

pancreas:7.79

breast:7.78

salivary:6

CAGE

uterus:4.02

placenta:2.16

prostate:1.41

ovary:2.88

testis:0

heart:-

muscle:-

esophagus:-

stomach:2.16

intestine:3.83

colon:3.97

liver/hepato:1.12

lung:2.31

bladder:2.49

kidney:-

pituitary:0.99

thyroid/parathyroid:-

adrenal gland:1.58

pancreas:3.36

breast:3.64

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:1.40

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:2.45

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_008965
Gene ID	19219
Unigene ID	Mm.18509
Probe set ID	1424208_at [Mouse430_2]
Ensembl ID	ENSMUSG00000039942

Orthologous Gene

Human[2]	NM_000958
Rat [0]

Chromosomal Region

15A1 [5,156,661 - 5,194,187]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000276	7TM GPCR, rhodopsin-like
IPR017452	GPCR, rhodopsin-like superfamily
IPR001244	Prostaglandin DP receptor
IPR001758	Prostanoid EP4 receptor
IPR008365	Prostanoid receptor
IPR001105	Thromboxane receptor

Gene Ontology (GO ID)

Biological Process

GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway
GO:0060348	bone development
GO:0070371	ERK1 and ERK2 cascade
GO:0007186	G-protein coupled receptor protein signaling pathway
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger
GO:0007254	JNK cascade
GO:0050710	negative regulation of cytokine secretion
GO:0050728	negative regulation of inflammatory response
GO:0033624	negative regulation of integrin activation
GO:0050715	positive regulation of cytokine secretion
GO:0050729	positive regulation of inflammatory response
GO:0030278	regulation of ossification
GO:0051492	regulation of stress fiber formation
GO:0032496	response to lipopolysaccharide
GO:0007165	signal transduction
GO:0042093	T-helper cell differentiation

Cellular Component

GO:0016021	integral to membrane
GO:0016020	membrane
GO:0005886	plasma membrane

Molecular Function

GO:0004930	G-protein coupled receptor activity
GO:0004957	prostaglandin E receptor activity
GO:0004955	prostaglandin receptor activity
GO:0004871	signal transducer activity

prostaglandin E receptor 4 (subtype EP4)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function