protein tyrosine phosphatase, receptor type, C

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Synonym

CD45 antigen, Cd45, L-CA, Ptprc, Ly-5, CD45, Leukocyte common antigen precursor, CD45R, Lymphocyte common antigen Ly-5, Lyt-4, loc, protein tyrosine phosphatase, receptor type, C, B220, T200

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.70 cerebellum:36.80 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:57.30 spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:518.50 peripheral blood:2717.20 spleen:1119.10 thymus:316.20 bone marrow:102.60 adipose:- bone:37.60 skin:23.80
GeneChip cerebrum:5.65 cerebellum:4.37 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:6.16 spine:5.59 retina:6.92 eye:6.48 artery/aorta:- vein:7.59 lymphnode:13.39 peripheral blood:- spleen:13.32 thymus:- bone marrow:12.44 adipose:8.45 bone:12.58 skin:8.87
CAGE cerebrum:0.91 cerebellum:- brain stem:0.85 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.04 retina:- eye:- artery/aorta:4.11 vein:- lymphnode:7.65 peripheral blood:- spleen:5.94 thymus:6.67 bone marrow:- adipose:- bone:5.15 skin:3.15
RNA-seq cerebrum:0.80 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:17.60     liver/hepato:-        lung:60.30    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:848.90 pancreas:18.80 breast:39.20 salivary:-
GeneChip uterus:9.83 placenta:6.59 prostate:6.94 ovary:8.14 testis:4.10 heart:7.47 muscle:8.13 esophagus:- stomach:7.21 intestine:8.71 colon:- liver/hepato:7.74 lung:10.32 bladder:7.99 kidney:7.01 pituitary:5.97 thyroid/parathyroid:- adrenal gland:8.38 pancreas:7.49 breast:10.22 salivary:8.82
CAGE uterus:3.34 placenta:2.09 prostate:2.00 ovary:2.93 testis:0.75 heart:- muscle:- esophagus:- stomach:2.26 intestine:2.89 colon:3.86     liver/hepato:2.85    lung:5.24 bladder:2.90 kidney:- pituitary:2.25 thyroid/parathyroid:- adrenal gland:3.70 pancreas:2.66 breast:3.99 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.45 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.31        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

IDs

Refseq ID NM_001111316
Gene ID 19264
Unigene ID Mm.391573
Probe set ID 1422124_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000026395

Orthologous Gene

Human[7]  NM_002838, NM_080921, NM_080923
Rat[16]  NM_001109887, NM_001109888, NM_001109889, NM_001109890, NM_138507

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

61878
62795
1290451
1350294
1431091
1454056
1683707
1686571
1822988
1834169
1932742
2522930
2567701
2574151
2574991
2744450
2845400
2885153
2886425
2894402
2944116
2948186
2955416
2971731
2978372
3037546
3211131
3384439
3416634
3417340
3489673
3570377
3817907
3864163
4042679
6233370
6602762
6607883
6610701
6983999
7287081
7477352
7477353
7499277
7509278
7511063
7558020
7558021
7562081
7589135
7630421
7688139
7743522
7751624
7806287
7807014
7882992
7889403
8041705
8043862
8046327
8101401
8175795
8288230
8334701
8452817
8551241
8552190
8566025
8566034
8570203
8632004
8661716
8666928
8692271
8747926
8747928
8759740
8788039
8875997
8903730
8954783
9015183
9064344
9107685
9120275
9148925
9190928
9197241
9208839
9254656
9285409
9324357
9376320
9581568
9613827
9725213
9740804
9754575
9794386
9828134
9870664
10067894
10330160
10330270
10349636
10358768
10397738
10403645
10429672
10458749
10508267
10556550
10575213
10631184
10648121
10749569
10770800
10829061
10848813
10906147
10926756
10943840
10943842
10970857
11042159
11076861
11093154
11163182
11201744
11217851
11260323
11342624
11466198
11476574
11544199
11698303
11716526
11884039
11994430
12004082
12022705
12049718
12055218
12068292
12091326
12115612
12207342
12209639
12244310
12244311
12391219
12391333
12393487
12414501
12466851
12477932
12496963
12499376
12612075
12648490
12714519
12731066
12805065
12900455
12902479
12922168
14563648
14567980
14609575
14625311
14691482
14715639
14749125
14987741
14990792
15067047
15070695
15128768
15138500
15155767
15210702
15240667
15294970
15302847
15342464
15358618
15383460
15459109
15485910
15499555
15514019
15530859
15548576
15557316
15661907
15677502
15681780
15687496
15699109
15723811
15778367
15790953
15795238
15823427
15845452
15845899
15857912
15867094
15909309
16020514
16025105
16141072
16141073
16287714
16319116
16332974
16356861
16361310
16378097
16455951
16473829
16493007
16502417
16505159
16517710
16602821
16616894
16621865
16627620
16709819
16771860
16809609
16815646
16856204
16860761
16912273
16925795
17159898
17177603
17213291
17277109
17277142
17287827
17339442
17383624
17404256
17420226
17507376
17517650
17521585
17655922
17683113
17719247
17762938
17804806
17846664
17855428
17897956
17923504
17923507
17941951
17954566
17991461
18059271
18086861
18086862
18086865
18178216
18195351
18249142
18337659
18374325
18403646
18413859
18426908
18448457
18495958
18523265
18550708
18552160
18566405
18591671
18602924
18627106
18628982
18653563
18684862
18725519
18762567
18769712
18779349
18922161
18941197
18952892
18981123
19001138
19008920
19015308
19060331
19129486
19135046
19164539
19164599
19234195
19246339
19269962
19299707
19332117
19380791
19428458
19478957
19571816
19683682
19727123
19728314
19765855
19783990
19838199
19841086
19875815
19901263
19920154
19934022
19995948
20043899
20130220
20208005
20346773
20382704
20505149
20606166
20624943
20625006
20660734
20679227
20709950
20802149
20805985
20856869
20876651
20890286
20978081
20980401
21098236
21108466
21173243
21181199
21245479
21267068
21273420
21282629
21300983
21355089
21423172
21460847
21464233
21469133
21502490
21502514
21515254
21572048
21606356
21613258
21633705
21636294
21788582
21816924
21825019
21883169
21911094
21990046
22018468
22033010
22046273
22048769
22072979
22078799
22135465
22144566
22194995
22354871
22354913
22387002
22387552
22406641
22415881
22425250
22442384
22464328
22504651
22538191
22552287
22558218
22670056
22677420
22682244
22726954
22727490
22753134
22786774
22837485
22848581
22902503
22988576
23018460
23029475
23092738
23233664
23248263
23315077
23315977
23319349
23334579
23362346
23396948
23530149
23536629
23554311
23563688
23580664
23585679
23601687
23624556
23636055
23636062
23644514
23744647
23750244
23812589
23878314
23883515
23904165
23913971
23928494
23936270
23997015
24029230
24123684
24141946
24143212
24255917
24478402
24639353
24681564
24745333

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0030183  B cell differentiation
GO:0042100  B cell proliferation
GO:0050853  B cell receptor signaling pathway
GO:0048539  bone marrow development
GO:0051607  defense response to virus
GO:0016311  dephosphorylation
GO:0002244  hemopoietic progenitor cell differentiation
GO:0034113  heterotypic cell-cell adhesion
GO:0002378  immunoglobulin biosynthetic process
GO:0007159  leukocyte adhesion
GO:0008152  metabolic process
GO:0006933  negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0001960  negative regulation of cytokine-mediated signaling pathway
GO:0050732  negative regulation of peptidyl-tyrosine phosphorylation
GO:0031953  negative regulation of protein amino acid autophosphorylation
GO:0006469  negative regulation of protein kinase activity
GO:0001915  negative regulation of T cell mediated cytotoxicity
GO:0045060  negative thymic T cell selection
GO:0046641  positive regulation of alpha-beta T cell proliferation
GO:0050857  positive regulation of antigen receptor-mediated signaling pathway
GO:0030890  positive regulation of B cell proliferation
GO:0045588  positive regulation of gamma-delta T cell differentiation
GO:0002925  positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0048304  positive regulation of isotype switching to IgG isotypes
GO:0043410  positive regulation of MAPKKK cascade
GO:0045582  positive regulation of T cell differentiation
GO:0001916  positive regulation of T cell mediated cytotoxicity
GO:0002711  positive regulation of T cell mediated immunity
GO:0042102  positive regulation of T cell proliferation
GO:0045059  positive thymic T cell selection
GO:0006470  protein amino acid dephosphorylation
GO:0045577  regulation of B cell differentiation
GO:0050855  regulation of B cell receptor signaling pathway
GO:0051726  regulation of cell cycle
GO:0002923  regulation of humoral immune response mediated by circulating immunoglobulin
GO:0033261  regulation of S phase
GO:0051209  release of sequestered calcium ion into cytosol
GO:0010332  response to gamma radiation
GO:0048864  stem cell development
GO:0030217  T cell differentiation
GO:0042098  T cell proliferation
GO:0050852  T cell receptor signaling pathway

Cellular Component

GO:0009986  cell surface
GO:0009897  external side of plasma membrane
GO:0005925  focal adhesion
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0005886  plasma membrane

Molecular Function

GO:0043395  heparan sulfate proteoglycan binding
GO:0008201  heparin binding
GO:0016787  hydrolase activity
GO:0016791  phosphatase activity
GO:0004721  phosphoprotein phosphatase activity
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0004725  protein tyrosine phosphatase activity