serum/glucocorticoid regulated kinase 1

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Synonym

serum/glucocorticoid regulated kinase, Sgk, Serine/threonine-protein kinase Sgk1, Sgk1, Serum/glucocorticoid-regulated kinase 1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:8.70 cerebellum:18.40 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:64.30 eye:- artery/aorta:168.80 vein:- lymphnode:21.60 peripheral blood:158.10 spleen:197.50 thymus:98.80 bone marrow:38.50 adipose:212.70 bone:50.10 skin:7.90
GeneChip cerebrum:9.69 cerebellum:9.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:9.01 spine:10.95 retina:11.27 eye:10.44 artery/aorta:- vein:9.84 lymphnode:9.89 peripheral blood:- spleen:9.26 thymus:- bone marrow:8.51 adipose:9.38 bone:9.14 skin:10.61
CAGE cerebrum:4.75 cerebellum:- brain stem:4.30 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.66 retina:- eye:- artery/aorta:4.64 vein:- lymphnode:4.92 peripheral blood:- spleen:3.64 thymus:3.68 bone marrow:- adipose:- bone:4.18 skin:5.31
RNA-seq cerebrum:7.31 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:17.60     liver/hepato:45.30        lung:150.60    bladder:132.40 kidney:394.90 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:28.10 breast:137.10 salivary:108
GeneChip uterus:9.44 placenta:10.85 prostate:10.58 ovary:11.38 testis:5.54 heart:9.84 muscle:11.40 esophagus:- stomach:11.51 intestine:10.80 colon:- liver/hepato:8.65 lung:10.85 bladder:9.64 kidney:10.08 pituitary:7.68 thyroid/parathyroid:- adrenal gland:10.34 pancreas:8.60 breast:10.25 salivary:9.34
CAGE uterus:4.33 placenta:6.26 prostate:6.50 ovary:5.45 testis:2.41 heart:- muscle:- esophagus:- stomach:5.86 intestine:5.82 colon:5.39     liver/hepato:4.38    lung:5.16 bladder:4.10 kidney:- pituitary:3.72 thyroid/parathyroid:- adrenal gland:5.14 pancreas:5.42 breast:5.46 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:16.87 esophagus:- stomach:- intestine:- colon:-     liver/hepato:3.47        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001161848
Gene ID 20393
Unigene ID Mm.284059
Probe set ID 1416041_at  [Mouse430_2]
Ensembl ID ENSMUSG00000019970

Orthologous Gene

Human[4]  NM_001143676, NM_001143677, NM_001143678, NM_005627
Rat [0]  

Chromosomal Region

10A3  [21,601,990  -  21,719,709]

Gene Family (Interpro ID)

IPR000961  AGC-kinase, C-terminal
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7671812
8647846
8889548
10349636
10358046
10751222
10922068
11042159
11076861
11217851
11335130
11500984
11742982
12417564
12466851
12477932
12488318
12684516
12734207
12819125
12904583
14610273
14613977
14691545
15007040
15034090
15226823
15383658
15461589
15489334
15590995
15605386
15665527
15728833
15733869
15774535
15793248
15843443
15871460
15944189
15958725
16014448
16099816
16125969
16141072
16141073
16284089
16301823
16410368
16416336
16443776
16460280
16484615
16537821
16630541
16685564
16804076
16847254
16897044
16919269
16924469
17003223
17192279
17332896
17360471
17377066
17618452
17686958
17715136
17967808
18006588
18319604
18334630
18367651
18385268
18586672
18614997
18753797
18768591
18799693
18925875
18981174
19158347
19255508
19436108
19494170
19548318
19570885
19672619
19690383
19710534
19748978
19965929
20110688
20466724
20511724
20515807
20568246
20631674
20832730
20884880
21106690
21147854
21251236
21267068
21385992
21493770
21586695
21677750
21731673
21735060
21757730
21784856
21865597
21900244
22001908
22031864
22212557
22301619
22556335
22590650
22759972
22797923
23015548
23019294
23034940
23392695
23402912
23467085
23991167
24265802
24705297

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0032869  cellular response to insulin stimulus
GO:0006883  cellular sodium ion homeostasis
GO:0043402  glucocorticoid mediated signaling pathway
GO:0007616  long-term memory
GO:0007019  microtubule depolymerization
GO:0043066  negative regulation of apoptosis
GO:0031115  negative regulation of microtubule polymerization
GO:0048812  neuron projection morphogenesis
GO:0018105  peptidyl-serine phosphorylation
GO:0016310  phosphorylation
GO:0030307  positive regulation of cell growth
GO:0050775  positive regulation of dendrite morphogenesis
GO:0010765  positive regulation of sodium ion transport
GO:0006468  protein amino acid phosphorylation
GO:0051726  regulation of cell cycle
GO:0032880  regulation of protein localization
GO:0006974  response to DNA damage stimulus
GO:0006950  response to stress
GO:0008542  visual learning

Cellular Component

GO:0005737  cytoplasm
GO:0005783  endoplasmic reticulum
GO:0016020  membrane
GO:0005739  mitochondrion
GO:0043005  neuron projection
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane

Molecular Function

GO:0043423  3-phosphoinositide-dependent protein kinase binding
GO:0005524  ATP binding
GO:0048037  cofactor binding
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0048156  tau protein binding
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups