receptor tyrosine kinase-like orphan receptor 2

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Synonym

Ror2, mROR2, receptor tyrosine kinase-like orphan receptor 2, Neurotrophic tyrosine kinase, receptor-related 2, mRor2, Ntrkr2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:19.10 cerebellum:55.30 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:38.20 spine:- retina:- eye:15.20 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:25 skin:15.80
GeneChip cerebrum:4.31 cerebellum:4.42 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.49 spine:4.60 retina:4.22 eye:4.78 artery/aorta:- vein:7.52 lymphnode:4.49 peripheral blood:- spleen:4.96 thymus:- bone marrow:4.33 adipose:4.40 bone:4.61 skin:4.72
CAGE cerebrum:0.69 cerebellum:- brain stem:0.78 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:1.59 retina:- eye:- artery/aorta:1.11 vein:- lymphnode:0.71 peripheral blood:- spleen:0.62 thymus:0 bone marrow:- adipose:- bone:0.63 skin:2.56
RNA-seq cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:87.20 placenta:- prostate:- ovary:11.50 testis:- heart:55.80 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:9.10        lung:10    bladder:- kidney:16.10 pituitary:12.90 thyroid/parathyroid:- adrenal gland:- pancreas:75.10 breast:16.30 salivary:-
GeneChip uterus:7.41 placenta:4.55 prostate:5.80 ovary:5.51 testis:4.89 heart:4.45 muscle:4.53 esophagus:- stomach:5.75 intestine:5.31 colon:- liver/hepato:4.54 lung:4.62 bladder:6.21 kidney:4.49 pituitary:5.98 thyroid/parathyroid:- adrenal gland:4.71 pancreas:5.30 breast:4.75 salivary:4.74
CAGE uterus:3.82 placenta:0.98 prostate:1.87 ovary:2.88 testis:0.45 heart:- muscle:- esophagus:- stomach:1.91 intestine:2.27 colon:2.07     liver/hepato:0.26    lung:1.51 bladder:3.02 kidney:- pituitary:2.58 thyroid/parathyroid:- adrenal gland:1.92 pancreas:2.19 breast:0.49 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:0.75 esophagus:- stomach:- intestine:- colon:-     liver/hepato:0        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_013846
Gene ID 26564
Unigene ID Mm.342774
Probe set ID 1423428_at  [Mouse430_2]
Ensembl ID ENSMUSG00000021464

Orthologous Gene

Human[2]  NM_004560
Rat[1]  NM_001107339

Chromosomal Region

-

Gene Family (Interpro ID)

IPR020067  Frizzled-like domain
IPR000001  Kringle
IPR013806  Kringle-like fold
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR020685  Tyrosine-protein kinase
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020933  Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020763  Tyrosine-protein kinase, receptor ROR
IPR016247  Tyrosine-protein kinase, receptor ROR, subgroup
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

10231392
10349636
10651906
10700181
10700182
11042159
11076861
11114734
11217851
11429290
11455430
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12466851
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12839624
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14610273
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15375164
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15654020
15755804
15963767
16141072
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16602821
16602827
17101698
17496152
17572674
17967808
17986005
18215320
18351675
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18365018
18480165
18606138
18667433
18762249
18799693
18948417
19218498
19521566
19640924
19720827
19785987
19802008
19958813
20063415
20149452
20215527
20417196
20457807
20634318
20660756
21078818
21246660
21267068
21316585
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22024319
22128168
22216013
22328498
22343533
22344299
22771246
22956684
23142633
23850867
24590964
24670389

Gene Ontology  (GO ID)

Biological Process

GO:0001502  cartilage condensation
GO:0030154  cell differentiation
GO:0030538  embryonic genitalia morphogenesis
GO:0042472  inner ear morphogenesis
GO:0007254  JNK cascade
GO:0007275  multicellular organismal development
GO:0008285  negative regulation of cell proliferation
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0016310  phosphorylation
GO:0030335  positive regulation of cell migration
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006468  protein amino acid phosphorylation
GO:0007165  signal transduction
GO:0001501  skeletal system development
GO:0001756  somitogenesis
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007223  Wnt receptor signaling pathway, calcium modulating pathway
GO:0060071  Wnt receptor signaling pathway, planar cell polarity pathway

Cellular Component

GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0005109  frizzled binding
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0004714  transmembrane receptor protein tyrosine kinase activity
GO:0017147  Wnt-protein binding