adrenergic receptor kinase, beta 2

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Synonym

GRK3, AW551196, beta ARK2, adrenergic receptor kinase, beta 2, AI851927, Adrbk-2, 4833444A01Rik, Adrbk2, Bark-2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip nodata
CAGE cerebrum:3.14 cerebellum:- brain stem:2.75 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.54 retina:- eye:- artery/aorta:2.50 vein:- lymphnode:2.95 peripheral blood:- spleen:2.10 thymus:1.35 bone marrow:- adipose:- bone:2.09 skin:1.67
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip nodata
CAGE uterus:2.14 placenta:0.88 prostate:2.00 ovary:1.96 testis:3.00 heart:- muscle:- esophagus:- stomach:1.57 intestine:0.72 colon:1.77     liver/hepato:1.02    lung:2.61 bladder:1.92 kidney:- pituitary:2.29 thyroid/parathyroid:- adrenal gland:2.22 pancreas:0.84 breast:2.02 salivary:-
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001035531
Gene ID 320129
Unigene ID -
Probe set ID -
Ensembl ID -

Orthologous Gene

Human [0]  
Rat [0]  

Chromosomal Region

5F  [113,339,498  -  113,444,811]

Gene Family (Interpro ID)

IPR000961  AGC-kinase, C-terminal
IPR001849  Pleckstrin homology
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR000342  Regulator of G protein signalling
IPR016137  Regulator of G protein signalling superfamily
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1869533
7761854
8035170
8638670
8889548
8917529
8955126
9325250
9345023
9365243
9802886
10198406
10338466
10349636
10922068
11042159
11076861
11217851
12466851
12794091
14610273
15140929
16141072
16141073
16602821
17344394
17698926
17959804
18165681
18554416
20534436
21267068
21677750
23935208

Gene Ontology  (GO ID)

Biological Process

GO:0002029  desensitization of G-protein coupled receptor protein signaling pathway
GO:0043647  inositol phosphate metabolic process
GO:0006886  intracellular protein transport
GO:0016310  phosphorylation
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0031623  receptor internalization
GO:0046154  rhodopsin metabolic process
GO:0007165  signal transduction

Cellular Component

GO:0030424  axon
GO:0005929  cilium
GO:0044441  cilium part
GO:0005829  cytosol
GO:0043198  dendritic shaft
GO:0043197  dendritic spine
GO:0016020  membrane
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0045202  synapse
GO:0030018  Z disc

Molecular Function

GO:0005524  ATP binding
GO:0047696  beta-adrenergic receptor kinase activity
GO:0031748  D1 dopamine receptor binding
GO:0004703  G-protein coupled receptor kinase activity
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0005543  phospholipid binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups