tyrosine kinase, non-receptor, 2

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Synonym

tyrosine kinase, non-receptor, 2, ACK1, Non-receptor protein tyrosine kinase Ack, P21cdc42Hs kinase, MGC37479, Ack, ACK-1, Pyk1, Cdgip, activated p21cdc42Hs kinase, AW552477, Tyrosine kinase non-receptor protein 2, Ack1, Tnk2, Activated CDC42 kinase 1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:102.50 cerebellum:110.50 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:210.20 spine:- retina:96.40 eye:98.80 artery/aorta:675.10 vein:- lymphnode:- peripheral blood:- spleen:13.20 thymus:168 bone marrow:- adipose:212.70 bone:62.60 skin:23.80
GeneChip cerebrum:10.36 cerebellum:9.88 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:9.58 spine:10.87 retina:9.74 eye:9.46 artery/aorta:- vein:9.20 lymphnode:9 peripheral blood:- spleen:9.22 thymus:- bone marrow:9.78 adipose:8.85 bone:9.48 skin:9.54
CAGE cerebrum:3.70 cerebellum:- brain stem:4.04 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.25 retina:- eye:- artery/aorta:3.33 vein:- lymphnode:1.78 peripheral blood:- spleen:3.11 thymus:3.11 bone marrow:- adipose:- bone:2.83 skin:3.01
RNA-seq cerebrum:27.57 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:130.90 placenta:69 prostate:- ovary:46 testis:14.80 heart:18.60 muscle:- esophagus:- stomach:- intestine:- colon:123.40     liver/hepato:36.20        lung:90.40    bladder:198.50 kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:37.50 breast:166.50 salivary:54
GeneChip uterus:8.47 placenta:8.93 prostate:9.02 ovary:8.38 testis:8.08 heart:7.99 muscle:8.74 esophagus:- stomach:9.45 intestine:8.57 colon:- liver/hepato:8.27 lung:8.22 bladder:9.99 kidney:7.38 pituitary:9.57 thyroid/parathyroid:- adrenal gland:8.62 pancreas:8.35 breast:9.50 salivary:9.55
CAGE uterus:2.16 placenta:3.02 prostate:4.05 ovary:2.25 testis:2.12 heart:- muscle:- esophagus:- stomach:4.93 intestine:3.71 colon:3.86     liver/hepato:3.22    lung:2.33 bladder:4.04 kidney:- pituitary:2.73 thyroid/parathyroid:- adrenal gland:2.41 pancreas:2.33 breast:5.07 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:3.47 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.60        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_016788
Gene ID 51789
Unigene ID Mm.251115
Probe set ID 1448297_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000022791

Orthologous Gene

Human[4]  NM_001010938, NM_005781
Rat[1]  NM_001008336, NM_005781

Chromosomal Region

16B3  [32,643,960  -  32,683,579]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8861907
10349636
10922068
11042159
11076861
11114734
11217851
12466851
12477932
14610273
15489334
16052498
16141072
16141073
16602821
16750431
16777958
17182860
17967808
18799693
20086093
20333297
21169560
21267068
21677750
22322295
22566699
22952966

Gene Ontology  (GO ID)

Biological Process

GO:0006897  endocytosis
GO:0016310  phosphorylation
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0006468  protein amino acid phosphorylation

Cellular Component

GO:0030424  axon
GO:0030054  cell junction
GO:0043025  cell soma
GO:0030136  clathrin-coated vesicle
GO:0005905  coated pit
GO:0005737  cytoplasm
GO:0031410  cytoplasmic vesicle
GO:0030425  dendrite
GO:0005768  endosome
GO:0070436  Grb2-EGFR complex
GO:0030426  growth cone
GO:0016020  membrane
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0005154  epidermal growth factor receptor binding
GO:0016301  kinase activity
GO:0046872  metal ion binding
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0004712  protein serine/threonine/tyrosine kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0050699  WW domain binding