pleckstrin

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Synonym

Pleckstrin, pleckstrin, 2010300B13Rik, Plek

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:15.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:94.60 retina:- eye:- artery/aorta:168.80 vein:- lymphnode:194.40 peripheral blood:100.60 spleen:250.20 thymus:59.30 bone marrow:448.80 adipose:- bone:75.10 skin:15.80
GeneChip cerebrum:5.84 cerebellum:5.34 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.43 spine:5.49 retina:4.07 eye:4.17 artery/aorta:- vein:6.03 lymphnode:10.12 peripheral blood:- spleen:10.48 thymus:- bone marrow:11.62 adipose:5.39 bone:11.56 skin:4.26
CAGE cerebrum:2.17 cerebellum:- brain stem:2.33 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.45 retina:- eye:- artery/aorta:3.37 vein:- lymphnode:4.93 peripheral blood:- spleen:4.63 thymus:2.49 bone marrow:- adipose:- bone:5.18 skin:1.86
RNA-seq cerebrum:0.79 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:43.60 placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:37 colon:35.20     liver/hepato:54.30        lung:30.10    bladder:66.20 kidney:- pituitary:155 thyroid/parathyroid:- adrenal gland:- pancreas:65.70 breast:3.30 salivary:54
GeneChip uterus:6.12 placenta:5.01 prostate:4.54 ovary:5.15 testis:3.79 heart:6.07 muscle:5.05 esophagus:- stomach:4.34 intestine:5.25 colon:- liver/hepato:4.57 lung:8.30 bladder:5.23 kidney:4.56 pituitary:4.67 thyroid/parathyroid:- adrenal gland:4.74 pancreas:5.15 breast:6.19 salivary:4.96
CAGE uterus:2.80 placenta:2.21 prostate:1.41 ovary:2.22 testis:0.75 heart:- muscle:- esophagus:- stomach:1.07 intestine:1.29 colon:1.89     liver/hepato:1.58    lung:4.36 bladder:2.07 kidney:- pituitary:1.81 thyroid/parathyroid:- adrenal gland:3.27 pancreas:0.84 breast:2.24 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.21 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.38        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_019549
Gene ID 56193
Unigene ID Mm.98232
Probe set ID 1448749_at  [Mouse430_2]
Ensembl ID ENSMUSG00000020120

Orthologous Gene

Human[2]  NM_002664
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000591  DEP domain
IPR001849  Pleckstrin homology
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

10349636
10860665
11042159
11076861
11217851
12466851
12477932
15489334
15761153
16141072
16141073
19190246
21649580

Gene Ontology  (GO ID)

Biological Process

GO:0031532  actin cytoskeleton reorganization
GO:0030030  cell projection organization
GO:0030866  cortical actin cytoskeleton organization
GO:0030845  inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway
GO:0007229  integrin-mediated signaling pathway
GO:0045744  negative regulation of G-protein coupled receptor protein signaling pathway
GO:0010920  negative regulation of inositol phosphate biosynthetic process
GO:0046488  phosphatidylinositol metabolic process
GO:0070527  platelet aggregation
GO:0032233  positive regulation of actin filament bundle formation
GO:0030836  positive regulation of actin filament depolymerization
GO:0010925  positive regulation of inositol-polyphosphate 5-phosphatase activity
GO:0033625  positive regulation of integrin activation
GO:0010572  positive regulation of platelet activation
GO:0070528  protein kinase C signaling cascade
GO:0070560  protein secretion by platelet
GO:0060305  regulation of cell diameter
GO:0031529  ruffle organization
GO:0070493  thrombin receptor signaling pathway
GO:0006904  vesicle docking during exocytosis

Cellular Component

GO:0005737  cytoplasm
GO:0032587  ruffle membrane

Molecular Function

GO:0043325  phosphatidylinositol-3,4-bisphosphate binding
GO:0005543  phospholipid binding
GO:0042803  protein homodimerization activity
GO:0005080  protein kinase C binding