mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)

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Synonym

Mopa, 230kDa, OPA-1, Trap230, Med12, Tnrc11

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:66 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:32.10 eye:121.60 artery/aorta:- vein:- lymphnode:- peripheral blood:100.60 spleen:39.50 thymus:19.80 bone marrow:12.80 adipose:425.40 bone:75.10 skin:23.80
GeneChip cerebrum:7.61 cerebellum:8.59 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:8.09 spine:8.04 retina:7.31 eye:7.32 artery/aorta:- vein:8.16 lymphnode:9.98 peripheral blood:- spleen:9.93 thymus:- bone marrow:9.81 adipose:8.53 bone:8.88 skin:8.27
CAGE cerebrum:3.53 cerebellum:- brain stem:3.24 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.30 retina:- eye:- artery/aorta:4.11 vein:- lymphnode:4.79 peripheral blood:- spleen:3.98 thymus:4.11 bone marrow:- adipose:- bone:3.75 skin:3.71
RNA-seq cerebrum:2.12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:41.40 prostate:- ovary:- testis:51.70 heart:37.20 muscle:35.50 esophagus:- stomach:32.70 intestine:- colon:-     liver/hepato:18.10        lung:20.10    bladder:- kidney:8.10 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:9.40 breast:55.50 salivary:54
GeneChip uterus:9.30 placenta:8.71 prostate:9.03 ovary:8.94 testis:7.83 heart:8.38 muscle:8.52 esophagus:- stomach:8.37 intestine:8.57 colon:- liver/hepato:8.22 lung:8.84 bladder:8.56 kidney:8.24 pituitary:9.30 thyroid/parathyroid:- adrenal gland:8.82 pancreas:7.99 breast:8.58 salivary:8.72
CAGE uterus:3.79 placenta:3.48 prostate:3.42 ovary:3.68 testis:1.80 heart:- muscle:- esophagus:- stomach:3.25 intestine:3.02 colon:3.22     liver/hepato:3.11    lung:3.72 bladder:3.63 kidney:- pituitary:3.86 thyroid/parathyroid:- adrenal gland:3.64 pancreas:3.10 breast:3.08 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.13 esophagus:- stomach:- intestine:- colon:-     liver/hepato:3.46        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_021521
Gene ID 59024
Unigene ID Mm.20873
Probe set ID 1425585_at  [Mouse430_2]
Ensembl ID ENSMUSG00000079487

Orthologous Gene

Human[3]  NM_005120
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

2885744
9702738
10349636
11042159
11076861
11217851
12037571
12466851
12477932
15340084
15368895
16109376
16141072
16141073
16602821
19036726
20362541
20508642
20589884
20630950
20720539
21267068
21677750
23178117
23575864

Gene Ontology  (GO ID)

Biological Process

GO:0030521  androgen receptor signaling pathway
GO:0007507  heart development
GO:0030178  negative regulation of Wnt receptor signaling pathway
GO:0001843  neural tube closure
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0006355  regulation of transcription, DNA-dependent
GO:0019827  stem cell maintenance
GO:0030518  steroid hormone receptor signaling pathway
GO:0006367  transcription initiation from RNA polymerase II promoter
GO:0006351  transcription, DNA-dependent
GO:0060070  Wnt receptor signaling pathway through beta-catenin
GO:0060071  Wnt receptor signaling pathway, planar cell polarity pathway

Cellular Component

GO:0016592  mediator complex
GO:0005634  nucleus

Molecular Function

GO:0008013  beta-catenin binding
GO:0003682  chromatin binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0019904  protein domain specific binding
GO:0004872  receptor activity
GO:0046966  thyroid hormone receptor binding
GO:0003713  transcription coactivator activity
GO:0003712  transcription cofactor activity