PTEN induced putative kinase 1

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Synonym

PTEN-induced putative kinase protein 1, mFLJ00387, brpk, AW557854, Pink1, PTEN induced putative kinase 1, AU042772, BRPK, 1190006F07Rik

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:161.50 cerebellum:73.70 brain stem:31.80 corpus callosum/glia:- pineal gland:- peripheral nerve:57.30 spine:- retina:128.60 eye:182.40 artery/aorta:- vein:- lymphnode:10.80 peripheral blood:43.10 spleen:13.20 thymus:108.70 bone marrow:12.80 adipose:- bone:37.60 skin:142.50
GeneChip cerebrum:11.12 cerebellum:11.10 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:11.20 spine:11.85 retina:10.14 eye:10.07 artery/aorta:- vein:9.52 lymphnode:9.41 peripheral blood:- spleen:9.09 thymus:- bone marrow:9.70 adipose:10.82 bone:9.91 skin:10.46
CAGE cerebrum:5.51 cerebellum:- brain stem:6.00 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:6.07 retina:- eye:- artery/aorta:4.92 vein:- lymphnode:2.67 peripheral blood:- spleen:4.09 thymus:4.26 bone marrow:- adipose:- bone:5.20 skin:4.74
RNA-seq cerebrum:98.64 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:130.90 placenta:110.50 prostate:- ovary:23 testis:103.50 heart:- muscle:142 esophagus:- stomach:32.70 intestine:- colon:123.40     liver/hepato:172        lung:120.50    bladder:- kidney:185.40 pituitary:271.30 thyroid/parathyroid:224.90 adrenal gland:- pancreas:18.80 breast:202.40 salivary:378
GeneChip uterus:10.01 placenta:10.07 prostate:10.55 ovary:10.09 testis:10.43 heart:11.77 muscle:12.17 esophagus:- stomach:9.40 intestine:9.62 colon:- liver/hepato:10.57 lung:10.47 bladder:10.12 kidney:10.96 pituitary:10.02 thyroid/parathyroid:- adrenal gland:11.13 pancreas:10.23 breast:10.83 salivary:11.05
CAGE uterus:4.23 placenta:4.66 prostate:4.86 ovary:4.28 testis:6.06 heart:- muscle:- esophagus:- stomach:4.17 intestine:3.66 colon:4.81     liver/hepato:5.47    lung:4.94 bladder:4.75 kidney:- pituitary:4.75 thyroid/parathyroid:- adrenal gland:5.11 pancreas:4.93 breast:4.57 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:117.73 esophagus:- stomach:- intestine:- colon:-     liver/hepato:31.64        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_026880
Gene ID 68943
Unigene ID Mm.18539
Probe set ID 1451148_at  [Mouse430_2]
Ensembl ID ENSMUSG00000028756

Orthologous Gene

Human[2]  NM_032409
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8889548
10349636
10725249
10922068
11042159
11076861
11217851
11494141
12466851
12477932
14607334
14681479
14697668
15489334
15782199
16141072
16141073
16771836
17389931
17563363
17950257
18218782
18560593
18614015
18687899
18687901
19071114
19167501
19229105
19276113
19285945
19492057
19546216
19786829
19909785
20049710
20068297
20153330
20404107
20817094
20926611
20940149
21126574
21173115
21195752
21249202
21262209
21267068
21385841
21421046
21555650
21601636
21606348
21637291
21664494
21672589
21677750
21839811
21945539
22043175
22223879
22265660
22511790
22630785
22872702
23144451
23165879
23238720
23256036
23295771
23303188
23341629
23348839
23440919
23449626
23472196
23620051
23638067
23688429
23754282
24037540
24128678
24151868
24553947
24652937
24703837
24778451

Gene Ontology  (GO ID)

Biological Process

GO:0006914  autophagy
GO:0000422  mitochondrion degradation
GO:0043524  negative regulation of neuron apoptosis
GO:0018105  peptidyl-serine phosphorylation
GO:0016310  phosphorylation
GO:0033605  positive regulation of catecholamine secretion
GO:0033603  positive regulation of dopamine secretion
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0090200  positive regulation of release of cytochrome c from mitochondria
GO:0032226  positive regulation of synaptic transmission, dopaminergic
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade
GO:0043523  regulation of neuron apoptosis
GO:0043254  regulation of protein complex assembly
GO:0031396  regulation of protein ubiquitination
GO:0006950  response to stress

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0016021  integral to membrane
GO:0016020  membrane
GO:0005743  mitochondrial inner membrane
GO:0005741  mitochondrial outer membrane
GO:0005739  mitochondrion

Molecular Function

GO:0005524  ATP binding
GO:0010857  calcium-dependent protein kinase activity
GO:0016301  kinase activity
GO:0000287  magnesium ion binding
GO:0046872  metal ion binding
GO:0000166  nucleotide binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0055131  RING finger domain binding
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0031625  ubiquitin protein ligase binding