MAD2 mitotic arrest deficient-like 2 (yeast)

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Synonym

MAD2 mitotic arrest deficient-like 2 (yeast), MAD2-like 2, Mad2l2, REV7, 2310033C13Rik, Mitotic spindle assembly checkpoint protein MAD2B, MAD2B

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:36.50 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:236.40 retina:32.10 eye:7.60 artery/aorta:- vein:- lymphnode:- peripheral blood:43.10 spleen:- thymus:19.80 bone marrow:25.60 adipose:- bone:50.10 skin:23.80
GeneChip cerebrum:6.57 cerebellum:6.05 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:6.61 spine:7.14 retina:6.78 eye:6.32 artery/aorta:- vein:6.47 lymphnode:7.61 peripheral blood:- spleen:6.91 thymus:- bone marrow:7.35 adipose:7.53 bone:6.79 skin:6.71
CAGE cerebrum:2.26 cerebellum:- brain stem:2.64 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.98 retina:- eye:- artery/aorta:2.58 vein:- lymphnode:2.82 peripheral blood:- spleen:2.49 thymus:2.11 bone marrow:- adipose:- bone:2.59 skin:2.64
RNA-seq cerebrum:5.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:30.90 ovary:34.50 testis:170 heart:- muscle:71 esophagus:- stomach:98.20 intestine:- colon:17.60     liver/hepato:9.10        lung:40.20    bladder:- kidney:16.10 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:18.80 breast:16.30 salivary:54
GeneChip uterus:7.85 placenta:7.42 prostate:7.48 ovary:7.55 testis:11.27 heart:6.77 muscle:7.38 esophagus:- stomach:6.74 intestine:6.43 colon:- liver/hepato:8.39 lung:7.03 bladder:6.93 kidney:7.17 pituitary:6.78 thyroid/parathyroid:- adrenal gland:6.62 pancreas:6.85 breast:6.81 salivary:6.53
CAGE uterus:2.57 placenta:2.90 prostate:2.52 ovary:2.78 testis:6.33 heart:- muscle:- esophagus:- stomach:2.16 intestine:2.33 colon:2.00     liver/hepato:2.53    lung:2.61 bladder:2.56 kidney:- pituitary:2.53 thyroid/parathyroid:- adrenal gland:2.42 pancreas:2.19 breast:2.42 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:3.20 esophagus:- stomach:- intestine:- colon:-     liver/hepato:5.20        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_027985
Gene ID 71890
Unigene ID Mm.9648
Probe set ID 1460348_at  [Mouse430_2]
Ensembl ID ENSMUSG00000029003

Orthologous Gene

Human[2]  NM_001127325, NM_006341
Rat[1]  NM_001012106, NM_006341

Chromosomal Region

-

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

10349636
10922068
11042159
11076861
11125038
11217851
12466851
12477932
14610273
14657033
15489334
16141072
16141073
18676373
20360068
21267068
21677750
21690297
22700975
23463509
24009519
24100295
24356953

Gene Ontology  (GO ID)

Biological Process

GO:0007015  actin filament organization
GO:0007049  cell cycle
GO:0051301  cell division
GO:0042772  DNA damage response, signal transduction resulting in transcription
GO:0006302  double-strand break repair
GO:0007067  mitosis
GO:0060564  negative regulation of anaphase-promoting complex activity during mitotic cell cycle
GO:0010719  negative regulation of epithelial to mesenchymal transition
GO:0042177  negative regulation of protein catabolic process
GO:0010944  negative regulation of transcription by competitive promoter binding
GO:0043433  negative regulation of transcription factor activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0001558  regulation of cell growth
GO:0006355  regulation of transcription, DNA-dependent
GO:0006974  response to DNA damage stimulus
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005680  anaphase-promoting complex
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0005634  nucleus
GO:0005819  spindle
GO:0016035  zeta DNA polymerase complex

Molecular Function

GO:0008432  JUN kinase binding