histidine-rich glycoprotein

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Synonym

AI265597, Hrg, D18020, AW413091, D16JH2, histidine-rich glycoprotein, HRGP, HPRG

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:10.80 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:6.13 cerebellum:6.21 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.94 spine:6.30 retina:6.46 eye:7.05 artery/aorta:- vein:5.93 lymphnode:5.74 peripheral blood:- spleen:6.05 thymus:- bone marrow:5.69 adipose:6.02 bone:5.72 skin:6.50
CAGE cerebrum:0 cerebellum:- brain stem:0 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0 retina:- eye:- artery/aorta:1.43 vein:- lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:- bone:0 skin:0
RNA-seq cerebrum:10.79 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:319.60 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1086        lung:-    bladder:- kidney:8.10 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:54
GeneChip uterus:6.11 placenta:6.33 prostate:6.03 ovary:5.79 testis:6.58 heart:6.60 muscle:6.25 esophagus:- stomach:6.15 intestine:5.98 colon:- liver/hepato:13.36 lung:8.17 bladder:5.90 kidney:7 pituitary:6.06 thyroid/parathyroid:- adrenal gland:6.47 pancreas:6.55 breast:6.19 salivary:6.34
CAGE uterus:0 placenta:0 prostate:0 ovary:0 testis:0 heart:- muscle:- esophagus:- stomach:2.44 intestine:0 colon:0     liver/hepato:7.93    lung:0.17 bladder:0.46 kidney:- pituitary:0 thyroid/parathyroid:- adrenal gland:2.74 pancreas:0 breast:0 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:246.73        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_053176
Gene ID 94175
Unigene ID Mm.358794
Probe set ID 1449242_s_at  [Mouse430_2]
Ensembl ID ENSMUSG00000022877

Orthologous Gene

Human[2]  NM_000412
Rat[1]  NM_133428

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000010  Proteinase inhibitor I25, cystatin

Link to Pubmed  (Pubmed ID)

10849117
12466851
12477932
15220341
15499407
15748999
15869579
18797515
19903770
19968777
20587784
21264222
21267068
21677750
22348394
22374984
22808089
23395172
23793459

Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0007596  blood coagulation
GO:0006935  chemotaxis
GO:0050832  defense response to fungus
GO:0042730  fibrinolysis
GO:0007599  hemostasis
GO:0016525  negative regulation of angiogenesis
GO:0043537  negative regulation of blood vessel endothelial cell migration
GO:0007162  negative regulation of cell adhesion
GO:0033629  negative regulation of cell adhesion mediated by integrin
GO:0030308  negative regulation of cell growth
GO:0008285  negative regulation of cell proliferation
GO:0010951  negative regulation of endopeptidase activity
GO:0051918  negative regulation of fibrinolysis
GO:0010593  negative regulation of lamellipodium assembly
GO:0030168  platelet activation
GO:0043065  positive regulation of apoptosis
GO:0051894  positive regulation of focal adhesion formation
GO:0002839  positive regulation of immune response to tumor cell
GO:0032956  regulation of actin cytoskeleton organization
GO:0030193  regulation of blood coagulation
GO:0010468  regulation of gene expression
GO:0050730  regulation of peptidyl-tyrosine phosphorylation
GO:0010543  regulation of platelet activation
GO:0043254  regulation of protein complex assembly

Cellular Component

GO:0005576  extracellular region

Molecular Function

GO:0004869  cysteine-type endopeptidase inhibitor activity
GO:0020037  heme binding
GO:0043395  heparan sulfate proteoglycan binding
GO:0008201  heparin binding
GO:0019865  immunoglobulin binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0004867  serine-type endopeptidase inhibitor activity
GO:0008270  zinc ion binding