hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit

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Synonym

Mtpa, C77020, Hadha

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:71.20 cerebellum:- brain stem:63.60 corpus callosum/glia:- pineal gland:257.80 peripheral nerve:649.70 spine:94.60 retina:64.30 eye:144.40 artery/aorta:84.40 vein:- lymphnode:712.90 peripheral blood:43.10 spleen:171.20 thymus:29.60 bone marrow:64.10 adipose:- bone:125.20 skin:229.60
GeneChip cerebrum:8.62 cerebellum:8.81 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:9.55 spine:9.59 retina:6.29 eye:6.39 artery/aorta:- vein:9.26 lymphnode:10.07 peripheral blood:- spleen:9.59 thymus:- bone marrow:9.77 adipose:11.42 bone:9.36 skin:9.77
CAGE cerebrum:4.40 cerebellum:- brain stem:4.51 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.88 retina:- eye:- artery/aorta:7.20 vein:- lymphnode:5.15 peripheral blood:- spleen:4.68 thymus:4.83 bone marrow:- adipose:- bone:4.45 skin:5.23
RNA-seq cerebrum:16.71 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:41.40 prostate:30.90 ovary:68.90 testis:66.50 heart:279 muscle:213 esophagus:- stomach:196.40 intestine:- colon:105.70     liver/hepato:172        lung:90.40    bladder:330.90 kidney:129 pituitary:12.90 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:150.20 salivary:216
GeneChip uterus:10.08 placenta:9.22 prostate:10.07 ovary:10.70 testis:10.74 heart:12.46 muscle:11.14 esophagus:- stomach:10.96 intestine:10.76 colon:- liver/hepato:11.28 lung:9.82 bladder:9.97 kidney:10.41 pituitary:9.74 thyroid/parathyroid:- adrenal gland:10.76 pancreas:9.15 breast:10.99 salivary:9.14
CAGE uterus:4.99 placenta:4.58 prostate:4.80 ovary:5.47 testis:6.26 heart:- muscle:- esophagus:- stomach:5.60 intestine:6.36 colon:5.77     liver/hepato:6.40    lung:4.91 bladder:5.19 kidney:- pituitary:4.78 thyroid/parathyroid:- adrenal gland:5.62 pancreas:4.47 breast:5.38 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:38.66 esophagus:- stomach:- intestine:- colon:-     liver/hepato:61.40        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_178878
Gene ID 97212
Unigene ID Mm.200497
Probe set ID 1452173_at  [Mouse430_2]
Ensembl ID ENSMUSG00000025745

Orthologous Gene

Human[3]  NM_000182
Rat[2]  NM_130826

Chromosomal Region

-

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

10349636
10725249
10922068
11042159
11076861
11217851
11390422
12466851
12477932
12865426
14610273
14651853
14681479
15240869
15782199
15887119
16107646
16141072
16141073
17500595
18614015
21278135
21565611
21677750
22083510
24457600

Gene Ontology  (GO ID)

Biological Process

GO:0006635  fatty acid beta-oxidation
GO:0006631  fatty acid metabolic process
GO:0006629  lipid metabolic process
GO:0008152  metabolic process
GO:0055114  oxidation reduction
GO:0042493  response to drug
GO:0032868  response to insulin stimulus

Cellular Component

GO:0005737  cytoplasm
GO:0016507  fatty acid beta-oxidation multienzyme complex
GO:0005743  mitochondrial inner membrane
GO:0042645  mitochondrial nucleoid
GO:0005739  mitochondrion
GO:0005730  nucleolus

Molecular Function

GO:0003857  3-hydroxyacyl-CoA dehydrogenase activity
GO:0003988  acetyl-CoA C-acyltransferase activity
GO:0000062  acyl-CoA binding
GO:0003824  catalytic activity
GO:0050662  coenzyme binding
GO:0004300  enoyl-CoA hydratase activity
GO:0016509  long-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO:0016508  long-chain-enoyl-CoA hydratase activity
GO:0016829  lyase activity
GO:0051287  NAD or NADH binding
GO:0016491  oxidoreductase activity
GO:0016616  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0032403  protein complex binding