pyruvate dehydrogenase kinase, isozyme 1

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:36.90 spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:6.05 cerebellum:5.97 brain stem:6.04 corpus callosum/glia:- pineal gland:- peripheral nerve:6.33 spine:- retina:- eye:6.32 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:6.39 thymus:6.60 bone marrow:5.91 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:8.52 muscle:6.26 esophagus:- stomach:- intestine:6.40 colon:6.74 liver/hepato:- lung:- bladder:- kidney:5.75 pituitary:5.53 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_053826
Gene ID 116551
Unigene ID Rn.111855
Probe set ID L22294_at  [RG_U34A]
Ensembl ID ENSRNOG00000001517

Orthologous Gene

Human[1]  NM_002610
Mouse[2]  NM_172665

Chromosomal Region

3q22  [54,292,076  -  54,319,240]

Gene Family (Interpro ID)

IPR003594  ATPase-like, ATP-binding domain
IPR004358  Signal transduction histidine kinase-related protein, C-terminal

Link to Pubmed  (Pubmed ID)

8253790
9405293
11486000
11795479
12477932
12573248
15007074
17310282
22575885

Gene Ontology  (GO ID)

Biological Process

GO:0008283  cell proliferation
GO:0007166  cell surface receptor linked signal transduction
GO:0006006  glucose metabolic process
GO:0008631  induction of apoptosis by oxidative stress
GO:0018105  peptidyl-serine phosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0010510  regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010906  regulation of glucose metabolic process

Cellular Component

GO:0005759  mitochondrial matrix
GO:0005967  mitochondrial pyruvate dehydrogenase complex
GO:0005739  mitochondrion
GO:0045254  pyruvate dehydrogenase complex

Molecular Function

GO:0005524  ATP binding
GO:0032403  protein complex binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0004740  pyruvate dehydrogenase (acetyl-transferring) kinase activity