mitogen activated protein kinase kinase kinase 1

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:47.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:35.50 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:122.90 bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:5.87 cerebellum:6.41 brain stem:6.08 corpus callosum/glia:- pineal gland:- peripheral nerve:5.76 spine:- retina:- eye:6.40 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:6.92 thymus:6.46 bone marrow:6.74 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:151.80 ovary:- testis:- heart:58.20 muscle:1063 esophagus:- stomach:- intestine:209.30 colon:-     liver/hepato:13.30        lung:50.70    bladder:- kidney:63.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:227.60 breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:6.15 muscle:6 esophagus:- stomach:- intestine:6.47 colon:6.10 liver/hepato:- lung:- bladder:- kidney:6.34 pituitary:6.03 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_053887
Gene ID 116667
Unigene ID Rn.11081
Probe set ID U48596_at  [RG_U34A]
Ensembl ID ENSRNOG00000013177

Orthologous Gene

Human[1]  NM_005921
Mouse[1]  NM_011945

Chromosomal Region

2q14  [43,062,252  -  43,125,943]

Gene Family (Interpro ID)

IPR016024  Armadillo-type fold
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain
IPR018957  Zinc finger, C3HC4 RING-type
IPR011016  Zinc finger, RING-CH-type
IPR013083  Zinc finger, RING/FYVE/PHD-type
IPR007527  Zinc finger, SWIM-type

Link to Pubmed  (Pubmed ID)

7624324
8643568
9110999
9155015
9305638
9836645
11746500
11784851
12011049
12049732
12835716
15037605
15164763
16006144
16427076
16491099
17101801
17306896
17529967
17997823
18036273
18308848
21605499
22993404

Gene Ontology  (GO ID)

Biological Process

GO:0007256  activation of JNKK activity
GO:0007257  activation of JUN kinase activity
GO:0000186  activation of MAPKK activity
GO:0008637  apoptotic mitochondrial changes
GO:0043010  camera-type eye development
GO:0071260  cellular response to mechanical stimulus
GO:0007254  JNK cascade
GO:0000165  MAPKKK cascade
GO:0032232  negative regulation of actin filament bundle formation
GO:0018105  peptidyl-serine phosphorylation
GO:0030838  positive regulation of actin filament polymerization
GO:0043065  positive regulation of apoptosis
GO:0043507  positive regulation of JUN kinase activity
GO:0043406  positive regulation of MAP kinase activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0050434  positive regulation of viral transcription
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0051259  protein oligomerization
GO:0000209  protein polyubiquitination
GO:0042787  protein ubiquitination during ubiquitin-dependent protein catabolic process
GO:0030334  regulation of cell migration
GO:0006970  response to osmotic stress
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0042060  wound healing

Cellular Component

GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0016020  membrane

Molecular Function

GO:0005524  ATP binding
GO:0042802  identical protein binding
GO:0008432  JUN kinase binding
GO:0008545  JUN kinase kinase activity
GO:0004706  JUN kinase kinase kinase activity
GO:0004709  MAP kinase kinase kinase activity
GO:0051019  mitogen-activated protein kinase binding
GO:0031434  mitogen-activated protein kinase kinase binding
GO:0004672  protein kinase activity
GO:0019901  protein kinase binding
GO:0004674  protein serine/threonine kinase activity
GO:0046625  sphingolipid binding
GO:0004842  ubiquitin-protein ligase activity
GO:0008270  zinc ion binding