CASP8 and FADD-like apoptosis regulator

 jump to detail

Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:36.90 spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:78 thymus:122.90 bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:39.80 prostate:38 ovary:- testis:- heart:38.80 muscle:- esophagus:- stomach:- intestine:104.70 colon:-     liver/hepato:-        lung:101.30    bladder:- kidney:- pituitary:59.20 thyroid/parathyroid:- adrenal gland:- pancreas:56.90 breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001033864
Gene ID 117279
Unigene ID Rn.204752
Probe set ID -
Ensembl ID ENSRNOG00000012473

Orthologous Gene

Human[18]  NM_001127183, NM_001127184, NM_001202515, NM_001202516, NM_001202517, NM_001202518, NM_001202519, NM_003879
Mouse[4]  NM_009805, NM_207653, NM_001202515, NM_001202516, NM_001202517, NM_001202518, NM_001202519, NM_003879

Chromosomal Region

9q31  [57,309,836  -  57,356,635]

Gene Family (Interpro ID)

IPR001875  Death effector
IPR011029  DEATH-like
IPR011600  Peptidase C14, caspase catalytic
IPR015917  Peptidase C14, caspase precursor p45, core

Link to Pubmed  (Pubmed ID)

8889548
11925448
12135878
12477932
12477972
12811833
12947022
15774698
16493077
17403612
17518537
17658509
18292530
18314484
18566605
18726983
19107989
19239902
19961901
20427667
21903094

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0043066  negative regulation of apoptosis
GO:0043154  negative regulation of caspase activity
GO:0043085  positive regulation of catalytic activity
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0006508  proteolysis

Cellular Component

GO:0031265  CD95 death-inducing signaling complex
GO:0005737  cytoplasm
GO:0031264  death-inducing signaling complex

Molecular Function

GO:0004197  cysteine-type endopeptidase activity
GO:0008047  enzyme activator activity
GO:0002020  protease binding