integrin linked kinase

 jump to detail

Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:215.30 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:110.60 spine:- retina:- eye:71.10 artery/aorta:357.10 vein:- lymphnode:- peripheral blood:- spleen:312 thymus:122.90 bone marrow:- adipose:294.40 bone:39 skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:358.40 prostate:75.90 ovary:456.50 testis:164.70 heart:252 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:1116.90        lung:101.30    bladder:- kidney:127.60 pituitary:177.70 thyroid/parathyroid:- adrenal gland:- pancreas:113.80 breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_133409
Gene ID 170922
Unigene ID Rn.95042
Probe set ID -
Ensembl ID ENSRNOG00000018993

Orthologous Gene

Human[6]  NM_001014794, NM_001014795, NM_004517
Mouse[2]  NM_001161724, NM_010562, NM_004517

Chromosomal Region

1q33  [163,481,299  -  163,487,550]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

11133699
11304546
11448915
11704830
12144526
12477932
12629168
14550274
14581460
15489334
15528771
15704679
16170337
16201970
16493410
16679308
16728409
16941698
16962068
17021600
17167118
17182785
17194454
17234816
17490631
17934340
18037995
18080083
18252715
18336616
18535176
18602949
18702665
19215949
19489098
19629758
20347724
21084641
21350838
21928230
21949693
22064318

Gene Ontology  (GO ID)

Biological Process

GO:0001658  branching involved in ureteric bud morphogenesis
GO:0007569  cell aging
GO:0007050  cell cycle arrest
GO:0030030  cell projection organization
GO:0045197  establishment or maintenance of epithelial cell apical/basal polarity
GO:0043206  fibril organization
GO:0007229  integrin-mediated signaling pathway
GO:0032288  myelin assembly
GO:0022011  myelination in the peripheral nervous system
GO:0043066  negative regulation of apoptosis
GO:0010667  negative regulation of cardiac muscle cell apoptosis
GO:0043524  negative regulation of neuron apoptosis
GO:0006469  negative regulation of protein kinase activity
GO:0014912  negative regulation of smooth muscle cell migration
GO:0048662  negative regulation of smooth muscle cell proliferation
GO:0021675  nerve development
GO:0048812  neuron projection morphogenesis
GO:0018105  peptidyl-serine phosphorylation
GO:0045773  positive regulation of axon extension
GO:0050772  positive regulation of axonogenesis
GO:0030513  positive regulation of BMP signaling pathway
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0001954  positive regulation of cell-matrix adhesion
GO:0050775  positive regulation of dendrite morphogenesis
GO:0043406  positive regulation of MAP kinase activity
GO:0043410  positive regulation of MAPKKK cascade
GO:0045663  positive regulation of myoblast differentiation
GO:0045669  positive regulation of osteoblast differentiation
GO:0042327  positive regulation of phosphorylation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006468  protein amino acid phosphorylation
GO:0051291  protein heterooligomerization
GO:0043491  protein kinase B signaling cascade
GO:0032956  regulation of actin cytoskeleton organization
GO:0001558  regulation of cell growth
GO:0014044  Schwann cell development
GO:0034446  substrate adhesion-dependent cell spreading

Cellular Component

GO:0030424  axon
GO:0043025  cell soma
GO:0005911  cell-cell junction
GO:0043034  costamere
GO:0005737  cytoplasm
GO:0043198  dendritic shaft
GO:0005925  focal adhesion
GO:0030027  lamellipodium
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0030017  sarcomere
GO:0001725  stress fiber
GO:0043195  terminal button

Molecular Function

GO:0005524  ATP binding
GO:0005178  integrin binding
GO:0005515  protein binding
GO:0019904  protein domain specific binding
GO:0004672  protein kinase activity
GO:0019901  protein kinase binding
GO:0004674  protein serine/threonine kinase activity
GO:0017124  SH3 domain binding
GO:0004871  signal transducer activity