insulin-like growth factor 1

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Synonym

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Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:177.70 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:441.60 bone:78.10 skin:235.40
GeneChip cerebrum:5.58 cerebellum:4.87 brain stem:5.01 corpus callosum/glia:- pineal gland:- peripheral nerve:4.83 spine:- retina:- eye:5.93 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:5.37 thymus:5.38 bone marrow:5.39 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:228.20 testis:- heart:116.30 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:465.40        lung:50.70    bladder:- kidney:- pituitary:118.40 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:5.64 muscle:5.84 esophagus:- stomach:- intestine:5.32 colon:5.34 liver/hepato:- lung:- bladder:- kidney:5.54 pituitary:5.05 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

IDs

Refseq ID NM_001082477
Gene ID 24482
Unigene ID Rn.6282
Probe set ID X06107_i_at  [RG_U34A]
Ensembl ID ENSRNOG00000004517

Orthologous Gene

Human[14]  NM_000618, NM_001111283, NM_001111284, NM_001111285
Mouse[13]  NM_001111274, NM_001111275, NM_001111276, NM_010512, NM_184052

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1368571
1605853
2538424
2772560
3034909
3453891
3595538
3619921
3652906
3658684
7608381
8493451
8528247
8674839
8857020
8889548
9135074
9347796
9716657
9857239
10727985
10827403
10973501
11181517
11474477
11572795
11672597
11675876
11701291
11796174
11834488
11849991
11914039
11934830
11964096
11999215
12002507
12006713
12021178
12057928
12115579
12130673
12135130
12139923
12223347
12239091
12352620
12388149
12395318
12415260
12477932
12485837
12586785
12588046
12593720
12612011
12624094
12624434
12626499
12637793
12682066
12692175
12700634
12704096
12706025
12719647
12764579
12773315
12800242
12819007
12835956
12837295
12876289
12902319
12957504
12960075
13129855
14506616
14512843
14532269
14592960
14624474
14711902
14716834
14997011
15042585
15050532
15060019
15070850
15272025
15284206
15356074
15476580
15489316
15521962
15530650
15544842
15567334
15609625
15611844
15625284
15632127
15653207
15668985
15701575
15790724
15793718
15800930
15831712
15833775
15845077
15862547
15917159
15990634
15996002
16005252
16010989
16046480
16077083
16083987
16139950
16150839
16168389
16169204
16169763
16181175
16204335
16204415
16227402
16288470
16306169
16339156
16339387
16340176
16406300
16408277
16431135
16434425
16448778
16464236
16500767
16585854
16614058
16635594
16645019
16650607
16698918
16763033
16782835
16792806
16793032
16838042
16867182
16869890
16871256
16873705
16882007
16882751
16887362
16897348
16909201
16941139
16949134
16999977
17003344
17023532
17033095
17038487
17103039
17123939
17194636
17241280
17289286
17299765
17328060
17350303
17363111
17382293
17400715
17412794
17567960
17574386
17626604
17804753
17852404
17915215
17916769
17959844
17982240
18021255
18202785
18255192
18256135
18293375
18344903
18467435
18469139
18502759
18545223
18552658
18590691
18597865
18607346
18661273
18666320
18669936
18671941
18676006
18782533
18801338
18832087
18832567
18841527
18922796
18986336
19008912
19064563
19088829
19115393
19125275
19156625
19171036
19180987
19220704
19231997
19245789
19246225
19264110
19295919
19327374
19332057
19343576
19359426
19359918
19364764
19375852
19382144
19382214
19397962
19406747
19437499
19438508
19453943
19509289
19587145
19720043
19726620
19726638
19766709
19816949
19850049
19899713
19911128
19916171
19920079
19926099
20013160
20039316
20042609
20085549
20097715
20098680
20160126
20200966
20207740
20213470
20214047
20235220
20347065
20350589
20378540
20435602
20525067
20535993
20555424
20563856
20577844
20661454
20668042
20713758
20849920
20942583
21037532
21054577
21108784
21162126
21241374
21241779
21279379
21296499
21343254
21402727
21428190
21515376
21592969
21598309
21606872
21739215
21750148
21788435
21840378
21854769
21867412
21924541
21940672
21976954
22080499
22104347
22159761
22172933
22228770
22332214
22341695
22342912
22393433
22413999
22461702
22490886
22496359
22509095
22565577
22568219
22579999
22583947
22592456
22645024
22696074
22714676
22720172
22729283
22735908
22739109
22752413
22758598
22797316
22805023
22820932
22865430
22964493
22995212
23016131
23016132
23142791
23152492
23185594
23197685
23255067
23292283
23331186
23340251
23342276
23359486
23454400
23457189
23480228
23528977
23532711
23584855
23658701
23681983
23709620
23721666
23745035
23774069
23843538
23865718
24029240
24049436
24188094
24423253
24440782
24499417
24530896
24617524

Gene Ontology  (GO ID)

Biological Process

GO:0001974  blood vessel remodeling
GO:0048754  branching morphogenesis of a tube
GO:0048468  cell development
GO:0050650  chondroitin sulfate proteoglycan biosynthetic process
GO:0031017  exocrine pancreas development
GO:0007565  female pregnancy
GO:0010001  glial cell differentiation
GO:0048839  inner ear development
GO:0048009  insulin-like growth factor receptor signaling pathway
GO:0048286  lung alveolus development
GO:0030324  lung development
GO:0060463  lung lobe morphogenesis
GO:0060426  lung vasculature development
GO:0030879  mammary gland development
GO:0007613  memory
GO:0035264  multicellular organism growth
GO:0014896  muscle hypertrophy
GO:0045445  myoblast differentiation
GO:0051450  myoblast proliferation
GO:0014904  myotube cell development
GO:0060766  negative regulation of androgen receptor signaling pathway
GO:0043066  negative regulation of apoptosis
GO:0043154  negative regulation of caspase activity
GO:0008285  negative regulation of cell proliferation
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0090201  negative regulation of release of cytochrome c from mitochondria
GO:0034392  negative regulation of smooth muscle cell apoptosis
GO:0007399  nervous system development
GO:0048015  phosphoinositide-mediated signaling
GO:0042104  positive regulation of activated T cell proliferation
GO:0070886  positive regulation of calcineurin-NFAT signaling pathway
GO:0010613  positive regulation of cardiac muscle hypertrophy
GO:0030307  positive regulation of cell growth
GO:0008284  positive regulation of cell proliferation
GO:0043388  positive regulation of DNA binding
GO:0045740  positive regulation of DNA replication
GO:0050679  positive regulation of epithelial cell proliferation
GO:0045600  positive regulation of fat cell differentiation
GO:0048146  positive regulation of fibroblast proliferation
GO:0046326  positive regulation of glucose import
GO:0045725  positive regulation of glycogen biosynthetic process
GO:0045821  positive regulation of glycolysis
GO:0021940  positive regulation of granule cell precursor proliferation
GO:0043568  positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043410  positive regulation of MAPKKK cascade
GO:0045840  positive regulation of mitosis
GO:0045669  positive regulation of osteoblast differentiation
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0033160  positive regulation of protein import into nucleus, translocation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0046579  positive regulation of Ras protein signal transduction
GO:0014911  positive regulation of smooth muscle cell migration
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0090031  positive regulation of steroid hormone biosynthetic process
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0042523  positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0060527  prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060740  prostate gland epithelium morphogenesis
GO:0060736  prostate gland growth
GO:0060741  prostate gland stromal morphogenesis
GO:0030166  proteoglycan biosynthetic process
GO:0051924  regulation of calcium ion transport
GO:0042127  regulation of cell proliferation
GO:0032878  regulation of establishment or maintenance of cell polarity
GO:0040014  regulation of multicellular organism growth
GO:0001932  regulation of protein amino acid phosphorylation
GO:0051246  regulation of protein metabolic process
GO:0006417  regulation of translation
GO:0014823  response to activity
GO:0051384  response to glucocorticoid stimulus
GO:0032496  response to lipopolysaccharide
GO:0009612  response to mechanical stimulus
GO:0031667  response to nutrient levels
GO:0014070  response to organic cyclic substance
GO:0010033  response to organic substance
GO:0048545  response to steroid hormone stimulus
GO:0014834  satellite cell maintenance involved in skeletal muscle regeneration
GO:0060509  Type I pneumocyte differentiation
GO:0060510  Type II pneumocyte differentiation
GO:0030104  water homeostasis

Cellular Component

GO:0005615  extracellular space
GO:0005614  interstitial matrix

Molecular Function

GO:0008083  growth factor activity
GO:0005179  hormone activity
GO:0005158  insulin receptor binding
GO:0005159  insulin-like growth factor receptor binding
GO:0005178  integrin binding
GO:0005515  protein binding
GO:0043539  protein serine/threonine kinase activator activity
GO:0005496  steroid binding