insulin-like growth factor binding protein 3

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:35.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:284.30 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:195.20 skin:470.80
GeneChip cerebrum:5.61 cerebellum:5.33 brain stem:5.65 corpus callosum/glia:- pineal gland:- peripheral nerve:5.30 spine:- retina:- eye:5.53 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:6.58 thymus:5.86 bone marrow:5.73 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:79.60 prostate:- ovary:114.10 testis:- heart:232.70 muscle:265.70 esophagus:- stomach:- intestine:- colon:-     liver/hepato:39.90        lung:152    bladder:- kidney:- pituitary:59.20 thyroid/parathyroid:- adrenal gland:- pancreas:170.70 breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:6.50 muscle:6.11 esophagus:- stomach:- intestine:7.40 colon:6.68 liver/hepato:- lung:- bladder:- kidney:7.99 pituitary:6.08 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_012588
Gene ID 24484
Unigene ID Rn.26369
Probe set ID rc_AI009405_s_at  [RG_U34A]
Ensembl ID ENSRNOG00000008645

Orthologous Gene

Human[8]  NM_000598, NM_001013398
Mouse[1]  NM_008343, NM_001013398

Chromosomal Region

14q21  [87,959,153  -  87,967,097]

Gene Family (Interpro ID)

IPR009030  Growth factor, receptor

Link to Pubmed  (Pubmed ID)

1689154
2443135
2480123
2480787
3190697
7530650
8674839
9346943
10069662
11572795
12002507
12397024
12477932
12485812
12485840
12508914
12544349
12581876
12586785
12925957
13129855
14675666
15006930
15055478
15060019
15159305
15298948
15356074
15521962
15625284
15681824
15732261
15844718
15845624
15862547
15956343
15990634
16005252
16037377
16055936
16098781
16180585
16340176
16445635
16887362
17003344
17082888
17237715
17287408
17332286
17541304
17668637
17709267
17724372
17952116
18068478
18076934
19382144
19844724
19887447
19916171
20498031
20519361
21788435
22008548
22067319
22758598
22792172

Gene Ontology  (GO ID)

Biological Process

GO:0008285  negative regulation of cell proliferation
GO:0001933  negative regulation of protein amino acid phosphorylation
GO:0014912  negative regulation of smooth muscle cell migration
GO:0048662  negative regulation of smooth muscle cell proliferation
GO:0043065  positive regulation of apoptosis
GO:0043568  positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043410  positive regulation of MAPKKK cascade
GO:0045663  positive regulation of myoblast differentiation
GO:0006468  protein amino acid phosphorylation
GO:0001558  regulation of cell growth
GO:0010906  regulation of glucose metabolic process
GO:0040008  regulation of growth

Cellular Component

GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0042568  insulin-like growth factor binary complex
GO:0016942  insulin-like growth factor binding protein complex
GO:0042567  insulin-like growth factor ternary complex
GO:0005634  nucleus

Molecular Function

GO:0001968  fibronectin binding
GO:0005520  insulin-like growth factor binding
GO:0031994  insulin-like growth factor I binding
GO:0031995  insulin-like growth factor II binding
GO:0005515  protein binding
GO:0008160  protein tyrosine phosphatase activator activity