neurotrophic tyrosine kinase, receptor, type 2

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Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:335 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:147.50 spine:- retina:- eye:106.60 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:312 thymus:- bone marrow:- adipose:441.60 bone:- skin:-
GeneChip cerebrum:7.54 cerebellum:7.44 brain stem:7.69 corpus callosum/glia:- pineal gland:- peripheral nerve:6.81 spine:- retina:- eye:6.06 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:5.93 thymus:5.97 bone marrow:6.09 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:39.80 prostate:38 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:296.10 thyroid/parathyroid:- adrenal gland:- pancreas:56.90 breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:5.77 muscle:6.07 esophagus:- stomach:- intestine:5.69 colon:5.91 liver/hepato:- lung:- bladder:- kidney:5.88 pituitary:6.27 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata


Refseq ID NM_001163169
Gene ID 25054
Unigene ID Rn.11246
Probe set ID M55291_at  [RG_U34A]
Ensembl ID ENSRNOG00000018839

Orthologous Gene

Human[14]  NM_001007097, NM_001018064, NM_001018065, NM_001018066, NM_006180
Mouse[3]  NM_001025074, NM_008745, NM_001018065, NM_001018066, NM_006180

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

Gene Ontology  (GO ID)

Biological Process

GO:0007568  aging
GO:0031547  brain-derived neurotrophic factor receptor signaling pathway
GO:0021954  central nervous system neuron development
GO:0021987  cerebral cortex development
GO:0007631  feeding behavior
GO:0014047  glutamate secretion
GO:0007612  learning
GO:0007616  long-term memory
GO:0060291  long-term synaptic potentiation
GO:0042490  mechanoreceptor differentiation
GO:0043524  negative regulation of neuron apoptosis
GO:0007528  neuromuscular junction development
GO:0030182  neuron differentiation
GO:0001764  neuron migration
GO:0048709  oligodendrocyte differentiation
GO:0048935  peripheral nervous system neuron development
GO:0050772  positive regulation of axonogenesis
GO:0008284  positive regulation of cell proliferation
GO:0010628  positive regulation of gene expression
GO:0043410  positive regulation of MAPKKK cascade
GO:0010976  positive regulation of neuron projection development
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0051968  positive regulation of synaptic transmission, glutamatergic
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0050773  regulation of dendrite development
GO:0043408  regulation of MAPKKK cascade
GO:0019222  regulation of metabolic process
GO:0046928  regulation of neurotransmitter secretion
GO:0051896  regulation of protein kinase B signaling cascade
GO:0032314  regulation of Rac GTPase activity
GO:0010996  response to auditory stimulus
GO:0046548  retinal rod cell development
GO:0001570  vasculogenesis

Cellular Component

GO:0030424  axon
GO:0043025  cell soma
GO:0009986  cell surface
GO:0005829  cytosol
GO:0030425  dendrite
GO:0043197  dendritic spine
GO:0010008  endosome membrane
GO:0060076  excitatory synapse
GO:0000139  Golgi membrane
GO:0030426  growth cone
GO:0005887  integral to plasma membrane
GO:0005622  intracellular
GO:0043679  nerve terminal
GO:0005886  plasma membrane
GO:0014069  postsynaptic density
GO:0045211  postsynaptic membrane
GO:0048786  presynaptic active zone
GO:0043195  terminal button

Molecular Function

GO:0005524  ATP binding
GO:0048403  brain-derived neurotrophic factor binding
GO:0060175  brain-derived neurotrophic factor receptor activity
GO:0046875  ephrin receptor binding
GO:0043121  neurotrophin binding
GO:0005030  neurotrophin receptor activity
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0004714  transmembrane receptor protein tyrosine kinase activity