platelet derived growth factor receptor, alpha polypeptide

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:71.80 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:36.90 spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:147.20 bone:39 skin:-
GeneChip cerebrum:7.10 cerebellum:6.22 brain stem:7.05 corpus callosum/glia:- pineal gland:- peripheral nerve:6.62 spine:- retina:- eye:6.68 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:6.92 thymus:5.69 bone marrow:5.34 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:39.80 prostate:38 ovary:- testis:- heart:135.70 muscle:- esophagus:- stomach:- intestine:314 colon:-     liver/hepato:-        lung:405.30    bladder:- kidney:127.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:7.32 muscle:6.39 esophagus:- stomach:- intestine:7.73 colon:8.22 liver/hepato:- lung:- bladder:- kidney:7.53 pituitary:5.54 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_012802
Gene ID 25267
Unigene ID Rn.55127
Probe set ID rc_AI232379_at  [RG_U34A]
Ensembl ID ENSRNOG00000002244

Orthologous Gene

Human[1]  NM_006206
Mouse[4]  NM_001083316, NM_011058

Chromosomal Region

14p11  [35,369,423  -  35,418,126]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR020685  Tyrosine-protein kinase
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR016243  Tyrosine-protein kinase, CSF-1/PDGF receptor
IPR020933  Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain
IPR009134  Tyrosine-protein kinase, vascular endothelial growth factor receptor (VEGFR), N-terminal

Link to Pubmed  (Pubmed ID)

2157969
7524068
7665222
8318539
8402626
8610136
8889548
11756433
11788434
11832339
11920744
11994382
12130557
12866380
14593115
14630792
14695158
14724432
15021824
15060019
15155567
15267171
15284118
15342968
15534218
15613744
15722379
15791568
16039137
16383039
16741576
16794827
17049587
17134509
17335807
17519529
18421086
18801569
19213942
19373754
19665498
19691150
19738159
19909480
20036247
20333648
21171332
21289081
21954875
23545158
24735959

Gene Ontology  (GO ID)

Biological Process

GO:0030325  adrenal gland development
GO:0009653  anatomical structure morphogenesis
GO:0055003  cardiac myofibril assembly
GO:0060326  cell chemotaxis
GO:0016477  cell migration
GO:0071230  cellular response to amino acid stimulus
GO:0007204  elevation of cytosolic calcium ion concentration
GO:0048701  embryonic cranial skeleton morphogenesis
GO:0048557  embryonic digestive tract morphogenesis
GO:0048704  embryonic skeletal system morphogenesis
GO:0008210  estrogen metabolic process
GO:0030198  extracellular matrix organization
GO:0060325  face morphogenesis
GO:0008585  female gonad development
GO:0042063  gliogenesis
GO:0001701  in utero embryonic development
GO:0048839  inner ear development
GO:0033327  Leydig cell differentiation
GO:0030324  lung development
GO:0001553  luteinization
GO:0030539  male genitalia development
GO:0010544  negative regulation of platelet activation
GO:0042475  odontogenesis of dentine-containing tooth
GO:0009887  organ morphogenesis
GO:0060021  palate development
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0048015  phosphoinositide-mediated signaling
GO:0070527  platelet aggregation
GO:0048008  platelet-derived growth factor receptor signaling pathway
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0045740  positive regulation of DNA replication
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0048146  positive regulation of fibroblast proliferation
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0010863  positive regulation of phospholipase C activity
GO:0046777  protein amino acid autophosphorylation
GO:0050920  regulation of chemotaxis
GO:0034097  response to cytokine stimulus
GO:0032355  response to estradiol stimulus
GO:0043627  response to estrogen stimulus
GO:0009725  response to hormone stimulus
GO:0055093  response to hyperoxia
GO:0010035  response to inorganic substance
GO:0010033  response to organic substance
GO:0048705  skeletal system morphogenesis
GO:0048010  vascular endothelial growth factor receptor signaling pathway
GO:0042060  wound healing

Cellular Component

GO:0009986  cell surface
GO:0005575  cellular_component
GO:0005737  cytoplasm
GO:0009897  external side of plasma membrane
GO:0005887  integral to plasma membrane
GO:0031226  intrinsic to plasma membrane
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0043548  phosphoinositide 3-kinase binding
GO:0005018  platelet-derived growth factor alpha-receptor activity
GO:0048407  platelet-derived growth factor binding
GO:0005161  platelet-derived growth factor receptor binding
GO:0046983  protein dimerization activity
GO:0042803  protein homodimerization activity
GO:0004714  transmembrane receptor protein tyrosine kinase activity
GO:0005021  vascular endothelial growth factor receptor activity