neural precursor cell expressed, developmentally down-regulated 4

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:681.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:1032.40 spine:- retina:- eye:142.20 artery/aorta:357.10 vein:- lymphnode:- peripheral blood:- spleen:702 thymus:- bone marrow:- adipose:1324.90 bone:859.10 skin:2354
GeneChip cerebrum:8.08 cerebellum:8.61 brain stem:8.01 corpus callosum/glia:- pineal gland:- peripheral nerve:7.14 spine:- retina:- eye:8.17 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:6.61 thymus:6.96 bone marrow:7.22 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:1139 placenta:438.10 prostate:303.70 ovary:798.80 testis:247 heart:484.70 muscle:1594.50 esophagus:- stomach:- intestine:837.30 colon:869.60     liver/hepato:359        lung:1013.20    bladder:- kidney:765.70 pituitary:947.50 thyroid/parathyroid:- adrenal gland:- pancreas:569 breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:7.53 muscle:8.02 esophagus:- stomach:- intestine:6.83 colon:7.38 liver/hepato:- lung:- bladder:- kidney:6.88 pituitary:8.51 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_012986
Gene ID 25489
Unigene ID Rn.99540
Probe set ID U50842_at  [RG_U34A]
Ensembl ID ENSRNOG00000006683

Orthologous Gene

Human[2]  NM_006154, NM_198400
Mouse[3]  NM_010890, NM_198400

Chromosomal Region

8q24  [77,252,565  -  77,337,393]

Gene Family (Interpro ID)

IPR000008  C2 calcium-dependent membrane targeting
IPR008973  C2 calcium/lipid-binding domain, CaLB
IPR018029  C2 membrane targeting protein
IPR001202  WW/Rsp5/WWP

Link to Pubmed  (Pubmed ID)

8665844
8889548
9227416
9923703
11248052
11323714
11527431
11805112
12654927
12947022
14645220
15677482
15908698
16172119
16571785
16885233
16931598
17322297
17726579
18174164
19051070
19125695
19835873
19864419
19953087
20100827
20237237
21199218
21936631
22417925
22745772
23639431
24236122

Gene Ontology  (GO ID)

Biological Process

GO:0002250  adaptive immune response
GO:0048514  blood vessel morphogenesis
GO:0034644  cellular response to UV
GO:0044111  development during symbiotic interaction
GO:0003197  endocardial cushion development
GO:0042921  glucocorticoid receptor signaling pathway
GO:0006955  immune response
GO:0007041  lysosomal transport
GO:0010766  negative regulation of sodium ion transport
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0010768  negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948  negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528  neuromuscular junction development
GO:0031175  neuron projection development
GO:0003151  outflow tract morphogenesis
GO:0046824  positive regulation of nucleocytoplasmic transport
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0045732  positive regulation of protein catabolic process
GO:0050847  progesterone receptor signaling pathway
GO:0070534  protein K63-linked ubiquitination
GO:0006513  protein monoubiquitination
GO:0006622  protein targeting to lysosome
GO:0016567  protein ubiquitination
GO:0042787  protein ubiquitination during ubiquitin-dependent protein catabolic process
GO:0032801  receptor catabolic process
GO:0031623  receptor internalization
GO:0048814  regulation of dendrite morphogenesis
GO:0034765  regulation of ion transmembrane transport
GO:0042391  regulation of membrane potential
GO:0050807  regulation of synapse organization
GO:0014894  response to denervation involved in regulation of muscle adaptation
GO:0042110  T cell activation
GO:0019089  transmission of virus
GO:0043162  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Cellular Component

GO:0005938  cell cortex
GO:0000785  chromatin
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005794  Golgi apparatus
GO:0005622  intracellular
GO:0016020  membrane
GO:0045121  membrane raft
GO:0005902  microvillus
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0000151  ubiquitin ligase complex

Molecular Function

GO:0031698  beta-2 adrenergic receptor binding
GO:0050815  phosphoserine binding
GO:0050816  phosphothreonine binding
GO:0070064  proline-rich region binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0019904  protein domain specific binding
GO:0070063  RNA polymerase binding
GO:0019871  sodium channel inhibitor activity
GO:0043130  ubiquitin binding
GO:0004842  ubiquitin-protein ligase activity