purinergic receptor P2X, ligand-gated ion channel, 1

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:5.83 cerebellum:5.63 brain stem:5.48 corpus callosum/glia:- pineal gland:- peripheral nerve:5.61 spine:- retina:- eye:6.08 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:6.26 thymus:6.09 bone marrow:7.13 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:265.70 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:101.30    bladder:- kidney:- pituitary:59.20 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:5.77 muscle:5.98 esophagus:- stomach:- intestine:6.19 colon:5.76 liver/hepato:- lung:- bladder:- kidney:5.74 pituitary:6.02 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001142367
Gene ID 25505
Unigene ID Rn.91176
Probe set ID X80477_at  [RG_U34A]
Ensembl ID ENSRNOG00000017606

Orthologous Gene

Human[1]  NM_002558
Mouse[2]  NM_008771

Chromosomal Region

10q24  [59,889,933  -  59,904,962]

Gene Family (Interpro ID)

IPR001429  P2X purinoreceptor
IPR003044  P2X1 purinoceptor
IPR003045  P2X2 purinoceptor
IPR003047  P2X4 purinoceptor

Link to Pubmed  (Pubmed ID)

2072913
7523951
11205062
12237343
12477932
12788520
12850289
12907444
14625300
14679185
15174083
15227655
15313628
15489334
15813988
16000618
16006561
16934235
17192669
17287520
17561003
18523136
18590708
19023961
19077126
19196799
20335318
20590593
21669492
22745172
22785548

Gene Ontology  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0006812  cation transport
GO:0046513  ceramide biosynthetic process
GO:0007320  insemination
GO:0034220  ion transmembrane transport
GO:0006811  ion transport
GO:0030168  platelet activation
GO:0043270  positive regulation of ion transport
GO:0051291  protein heterooligomerization
GO:0051260  protein homooligomerization
GO:0019228  regulation of action potential in neuron
GO:0008217  regulation of blood pressure
GO:0051924  regulation of calcium ion transport
GO:0006940  regulation of smooth muscle contraction
GO:0003056  regulation of vascular smooth muscle contraction
GO:0019229  regulation of vasoconstriction
GO:0033198  response to ATP
GO:0010033  response to organic substance
GO:0002554  serotonin secretion by platelet
GO:0035249  synaptic transmission, glutamatergic
GO:0042310  vasoconstriction

Cellular Component

GO:0031240  external side of cell outer membrane
GO:0016021  integral to membrane
GO:0045121  membrane raft
GO:0043005  neuron projection
GO:0005886  plasma membrane
GO:0045211  postsynaptic membrane
GO:0043234  protein complex

Molecular Function

GO:0005524  ATP binding
GO:0004931  ATP-gated cation channel activity
GO:0005261  cation channel activity
GO:0008144  drug binding
GO:0005515  protein binding
GO:0001614  purinergic nucleotide receptor activity
GO:0008270  zinc ion binding