NK2 homeobox 1

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:59.80 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:5.33 cerebellum:5.09 brain stem:5.04 corpus callosum/glia:- pineal gland:- peripheral nerve:5.25 spine:- retina:- eye:5.30 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:5.27 thymus:5.20 bone marrow:5.12 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:50.70    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:5.13 muscle:5.11 esophagus:- stomach:- intestine:5.10 colon:5.08 liver/hepato:- lung:- bladder:- kidney:5.24 pituitary:5.59 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_013093
Gene ID 25628
Unigene ID Rn.34265
Probe set ID X53858_at  [RG_U34A]
Ensembl ID ENSRNOG00000008644

Orthologous Gene

Human[4]  NM_001079668, NM_003317
Mouse[2]  NM_001146198, NM_009385

Chromosomal Region

6q23  [76,916,943  -  76,920,133]

Gene Family (Interpro ID)

IPR001356  Homeobox
IPR009057  Homeodomain-like
IPR012287  Homeodomain-related

Link to Pubmed  (Pubmed ID)

1976511
7980615
8282100
8625983
8898894
9214635
9430685
11161473
11854319
12122016
12388439
12441357
12730191
14970209
15060019
15173172
15181011
15893608
16220345
16260629
16627577
16970909
17245593
17371871
17412341
17464199
17504987
17706597
17729273
18167145
18239190
18395010
19906647
21046115
21055024
21282365
22356123
23894445

Gene Ontology  (GO ID)

Biological Process

GO:0048646  anatomical structure formation involved in morphogenesis
GO:0007411  axon guidance
GO:0007420  brain development
GO:0060441  branching involved in lung morphogenesis
GO:0021795  cerebral cortex cell migration
GO:0021892  cerebral cortex GABAergic interneuron differentiation
GO:0021895  cerebral cortex neuron differentiation
GO:0060486  Clara cell differentiation
GO:0046545  development of primary female sexual characteristics
GO:0031128  developmental induction
GO:0007492  endoderm development
GO:0007631  feeding behavior
GO:0030900  forebrain development
GO:0021798  forebrain dorsal/ventral pattern formation
GO:0021879  forebrain neuron differentiation
GO:0021877  forebrain neuron fate commitment
GO:0021759  globus pallidus development
GO:0021766  hippocampus development
GO:0042538  hyperosmotic salinity response
GO:0033327  Leydig cell differentiation
GO:0007626  locomotory behavior
GO:0030324  lung development
GO:0060430  lung saccule development
GO:0042696  menarche
GO:0030336  negative regulation of cell migration
GO:0010719  negative regulation of epithelial to mesenchymal transition
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0030512  negative regulation of transforming growth factor beta receptor signaling pathway
GO:0048663  neuron fate commitment
GO:0001764  neuron migration
GO:0048709  oligodendrocyte differentiation
GO:0009887  organ morphogenesis
GO:0007389  pattern specification process
GO:0006644  phospholipid metabolic process
GO:0021983  pituitary gland development
GO:0010628  positive regulation of gene expression
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0002016  regulation of blood volume by renin-angiotensin
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0006355  regulation of transcription, DNA-dependent
GO:0045471  response to ethanol
GO:0009725  response to hormone stimulus
GO:0032496  response to lipopolysaccharide
GO:0022029  telencephalon cell migration
GO:0021537  telencephalon development
GO:0030878  thyroid gland development
GO:0006351  transcription, DNA-dependent
GO:0060510  Type II pneumocyte differentiation

Cellular Component

GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0005515  protein binding
GO:0003705  RNA polymerase II transcription factor activity, enhancer binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity