neurotrophic tyrosine kinase, receptor, type 3

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:59.80 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:73.70 spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:104.70 colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:118.40 thyroid/parathyroid:- adrenal gland:- pancreas:56.90 breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_019248
Gene ID 29613
Unigene ID Rn.99639
Probe set ID -
Ensembl ID ENSRNOG00000018674

Orthologous Gene

Human[22]  NM_001007156, NM_001012338, NM_001243101, NM_002530
Mouse[4]  NM_008746, NM_182809, NM_001243101, NM_002530

Chromosomal Region

1q31  [133,925,530  -  134,302,139]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1488112
8494647
8494648
9541170
9856458
10027563
10209957
10494076
10908605
11175319
11248116
11295066
11743997
11849751
12075995
12388556
12471037
12477932
12605901
12858046
12882335
12882781
12944916
14499950
14557907
15247919
15304335
16941478
17072373
17316612
17532148
17584746
17686986
17967490
18517217
18585435
18957307
19036963
19141250
21221027
21441969
21456016
21783247
24316227

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0032148  activation of protein kinase B activity
GO:0032856  activation of Ras GTPase activity
GO:0071300  cellular response to retinoic acid
GO:0090102  cochlea development
GO:0042490  mechanoreceptor differentiation
GO:0019056  modulation by virus of host transcription
GO:0048712  negative regulation of astrocyte differentiation
GO:0060548  negative regulation of cell death
GO:0001933  negative regulation of protein amino acid phosphorylation
GO:0048665  neuron fate specification
GO:0001764  neuron migration
GO:0048691  positive regulation of axon extension involved in regeneration
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0010628  positive regulation of gene expression
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0050927  positive regulation of positive chemotaxis
GO:0046777  protein amino acid autophosphorylation
GO:0048678  response to axon injury
GO:0051412  response to corticosterone stimulus
GO:0045471  response to ethanol
GO:0006950  response to stress
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0000139  Golgi membrane
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0046875  ephrin receptor binding
GO:0005030  neurotrophin receptor activity
GO:0002039  p53 binding
GO:0004714  transmembrane receptor protein tyrosine kinase activity