receptor tyrosine kinase-like orphan receptor 2

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:23.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:39 skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:38 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001107339
Gene ID 306782
Unigene ID Rn.211583
Probe set ID -
Ensembl ID ENSRNOG00000010974

Orthologous Gene

Human[2]  NM_004560
Mouse[1]  NM_013846

Chromosomal Region

17p14  [17,735,999  -  17,917,032]

Gene Family (Interpro ID)

IPR020067  Frizzled-like domain
IPR013106  Immunoglobulin V-set
IPR003596  Immunoglobulin V-set, subgroup
IPR000001  Kringle
IPR013806  Kringle-like fold
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR020685  Tyrosine-protein kinase
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020933  Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020763  Tyrosine-protein kinase, receptor ROR
IPR016247  Tyrosine-protein kinase, receptor ROR, subgroup
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

15702250
22609204
23337931

Gene Ontology  (GO ID)

Biological Process

GO:0001502  cartilage condensation
GO:0030154  cell differentiation
GO:0030538  embryonic genitalia morphogenesis
GO:0042472  inner ear morphogenesis
GO:0007254  JNK cascade
GO:0008285  negative regulation of cell proliferation
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0030335  positive regulation of cell migration
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0001501  skeletal system development
GO:0001756  somitogenesis
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007223  Wnt receptor signaling pathway, calcium modulating pathway
GO:0060071  Wnt receptor signaling pathway, planar cell polarity pathway

Cellular Component

GO:0016021  integral to membrane

Molecular Function

GO:0005524  ATP binding
GO:0005109  frizzled binding
GO:0004714  transmembrane receptor protein tyrosine kinase activity
GO:0017147  Wnt-protein binding