Axl receptor tyrosine kinase

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:59.80 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:184.40 spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:234 thymus:368.70 bone marrow:- adipose:147.20 bone:- skin:235.40
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:39.80 prostate:113.90 ovary:114.10 testis:- heart:19.40 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:127.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001013147
Gene ID 308444
Unigene ID Rn.161805
Probe set ID -
Ensembl ID ENSRNOG00000020716

Orthologous Gene

Human[4]  NM_001699, NM_021913
Mouse[1]  NM_001190974, NM_009465

Chromosomal Region

1q21  [80,964,751  -  80,994,300]

Gene Family (Interpro ID)

IPR003961  Fibronectin, type III
IPR008957  Fibronectin, type III-like fold
IPR013106  Immunoglobulin V-set
IPR003596  Immunoglobulin V-set, subgroup
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

9758639
10528229
11290560
15380678
15619028
15731461
16285961
16362042
18292389
19027714
19252414
20479336
21270900
22606290

Gene Ontology  (GO ID)

Biological Process

GO:0043277  apoptotic cell clearance
GO:0001974  blood vessel remodeling
GO:0030154  cell differentiation
GO:0048469  cell maturation
GO:0016477  cell migration
GO:0008283  cell proliferation
GO:0031668  cellular response to extracellular stimulus
GO:0070301  cellular response to hydrogen peroxide
GO:0071222  cellular response to lipopolysaccharide
GO:0007167  enzyme linked receptor protein signaling pathway
GO:0034101  erythrocyte homeostasis
GO:0021885  forebrain cell migration
GO:0006954  inflammatory response
GO:0001779  natural killer cell differentiation
GO:0043066  negative regulation of apoptosis
GO:0032689  negative regulation of interferon-gamma production
GO:0051250  negative regulation of lymphocyte activation
GO:0043524  negative regulation of neuron apoptosis
GO:0032720  negative regulation of tumor necrosis factor production
GO:0001764  neuron migration
GO:0031100  organ regeneration
GO:0042698  ovulation cycle
GO:0006909  phagocytosis
GO:0030168  platelet activation
GO:0001961  positive regulation of cytokine-mediated signaling pathway
GO:0032825  positive regulation of natural killer cell differentiation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0043491  protein kinase B signaling cascade
GO:0032940  secretion by cell
GO:0007165  signal transduction
GO:0007283  spermatogenesis
GO:0034446  substrate adhesion-dependent cell spreading
GO:0042246  tissue regeneration
GO:0048771  tissue remodeling
GO:0060068  vagina development

Cellular Component

GO:0009986  cell surface
GO:0005615  extracellular space
GO:0016021  integral to membrane

Molecular Function

GO:0005524  ATP binding
GO:0019838  growth factor binding
GO:0032036  myosin heavy chain binding
GO:0001786  phosphatidylserine binding
GO:0043548  phosphoinositide 3-kinase binding
GO:0046982  protein heterodimerization activity
GO:0004714  transmembrane receptor protein tyrosine kinase activity