Tnf receptor-associated factor 2

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:23.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:71.10 artery/aorta:357.10 vein:- lymphnode:- peripheral blood:- spleen:234 thymus:- bone marrow:- adipose:- bone:78.10 skin:-
GeneChip cerebrum:7.64 cerebellum:7.54 brain stem:7.24 corpus callosum/glia:- pineal gland:- peripheral nerve:8.30 spine:- retina:- eye:7.65 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:7.46 thymus:7.65 bone marrow:7.46 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:75.90 ovary:- testis:247 heart:77.60 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:13.30        lung:-    bladder:- kidney:127.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:7.58 muscle:7.50 esophagus:- stomach:- intestine:7.29 colon:7.42 liver/hepato:- lung:- bladder:- kidney:7.23 pituitary:8.15 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001107815
Gene ID 311786
Unigene ID Rn.105232
Probe set ID rc_H32966_at  [RG_U34A]
Ensembl ID ENSRNOG00000006238

Orthologous Gene

Human[1]  NM_021138
Mouse[1]  NM_009422

Chromosomal Region

3p13  [3,693,125  -  3,717,332]

Gene Family (Interpro ID)

IPR002083  MATH
IPR012227  TNF receptor-associated factor TRAF
IPR008974  TRAF-like
IPR018957  Zinc finger, C3HC4 RING-type
IPR013083  Zinc finger, RING/FYVE/PHD-type

Link to Pubmed  (Pubmed ID)

9813034
10713108
12050113
12215209
12477932
12655295
12786973
15590916
17626074
19910209
20967881
23085193
24011916

Gene Ontology  (GO ID)

Biological Process

GO:0007250  activation of NF-kappaB-inducing kinase activity
GO:0043623  cellular protein complex assembly
GO:0034351  negative regulation of glial cell apoptosis
GO:0032743  positive regulation of interleukin-2 production
GO:0043507  positive regulation of JUN kinase activity
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0090073  positive regulation of protein homodimerization activity
GO:0002726  positive regulation of T cell cytokine production
GO:0051091  positive regulation of transcription factor activity
GO:0051865  protein autoubiquitination
GO:0030163  protein catabolic process
GO:0006461  protein complex assembly
GO:0051291  protein heterooligomerization
GO:0070207  protein homotrimerization
GO:0070534  protein K63-linked ubiquitination
GO:0042981  regulation of apoptosis
GO:0051023  regulation of immunoglobulin secretion
GO:0046328  regulation of JNK cascade
GO:0007165  signal transduction
GO:0033209  tumor necrosis factor-mediated signaling pathway

Cellular Component

GO:0005938  cell cortex
GO:0005737  cytoplasm
GO:0009898  internal side of plasma membrane
GO:0045121  membrane raft
GO:0043234  protein complex

Molecular Function

GO:0005174  CD40 receptor binding
GO:0019899  enzyme binding
GO:0042802  identical protein binding
GO:0031435  mitogen-activated protein kinase kinase kinase binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0019903  protein phosphatase binding
GO:0005102  receptor binding
GO:0046625  sphingolipid binding
GO:0031996  thioesterase binding
GO:0005164  tumor necrosis factor receptor binding
GO:0031625  ubiquitin protein ligase binding
GO:0004842  ubiquitin-protein ligase activity
GO:0008270  zinc ion binding