low density lipoprotein receptor-related protein 6

 jump to detail

Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:142.20 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:78 thymus:- bone marrow:- adipose:294.40 bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:79.60 prostate:38 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:152    bladder:- kidney:63.80 pituitary:118.40 thyroid/parathyroid:- adrenal gland:- pancreas:56.90 breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001107892
Gene ID 312781
Unigene ID Rn.32960
Probe set ID -
Ensembl ID ENSRNOG00000006338

Orthologous Gene

Human[4]  NM_002336
Mouse[2]  NM_008514

Chromosomal Region

4q43  [171,337,114  -  171,444,933]

Gene Family (Interpro ID)

IPR001881  EGF-like calcium-binding
IPR000742  EGF-like, type 3
IPR001258  NHL repeat

Link to Pubmed  (Pubmed ID)

12660824
15143170
15962290
18006602
18432252
18505732
18981475
20351274
20404321
21935433
23481549

Gene Ontology  (GO ID)

Biological Process

GO:0009952  anterior/posterior pattern formation
GO:0003401  axis elongation
GO:0060349  bone morphogenesis
GO:0046849  bone remodeling
GO:0060444  branching involved in mammary gland duct morphogenesis
GO:0042074  cell migration involved in gastrulation
GO:0016337  cell-cell adhesion
GO:0071397  cellular response to cholesterol
GO:0021587  cerebellum morphogenesis
GO:0021795  cerebral cortex cell migration
GO:0021987  cerebral cortex development
GO:0060026  convergent extension
GO:0009950  dorsal/ventral axis specification
GO:0007204  elevation of cytosolic calcium ion concentration
GO:0048596  embryonic camera-type eye morphogenesis
GO:0042733  embryonic digit morphogenesis
GO:0035115  embryonic forelimb morphogenesis
GO:0035116  embryonic hindlimb morphogenesis
GO:0030326  embryonic limb morphogenesis
GO:0009880  embryonic pattern specification
GO:0060059  embryonic retina morphogenesis in camera-type eye
GO:0035261  external genitalia morphogenesis
GO:0060325  face morphogenesis
GO:0030900  forebrain development
GO:0021943  formation of radial glial scaffolds
GO:0001702  gastrulation with mouth forming second
GO:0048699  generation of neurons
GO:0021872  generation of neurons in the forebrain
GO:0001947  heart looping
GO:0035108  limb morphogenesis
GO:0060603  mammary gland duct morphogenesis
GO:0060596  mammary placode formation
GO:0030901  midbrain development
GO:0030917  midbrain-hindbrain boundary development
GO:0002009  morphogenesis of an epithelium
GO:0050680  negative regulation of epithelial cell proliferation
GO:0045599  negative regulation of fat cell differentiation
GO:0001933  negative regulation of protein amino acid phosphorylation
GO:0006469  negative regulation of protein kinase activity
GO:0034392  negative regulation of smooth muscle cell apoptosis
GO:0030178  negative regulation of Wnt receptor signaling pathway
GO:0014033  neural crest cell differentiation
GO:0014029  neural crest formation
GO:0001843  neural tube closure
GO:0021915  neural tube development
GO:0042475  odontogenesis of dentine-containing tooth
GO:0060021  palate development
GO:0003344  pericardium morphogenesis
GO:0043065  positive regulation of apoptosis
GO:0045780  positive regulation of bone resorption
GO:0045787  positive regulation of cell cycle
GO:0002053  positive regulation of mesenchymal cell proliferation
GO:0045778  positive regulation of ossification
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0090009  primitive streak formation
GO:0021861  radial glial cell differentiation in the forebrain
GO:0090118  receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport
GO:0060284  regulation of cell development
GO:0042127  regulation of cell proliferation
GO:0045598  regulation of fat cell differentiation
GO:0030278  regulation of ossification
GO:0006355  regulation of transcription, DNA-dependent
GO:0051593  response to folic acid
GO:0043434  response to peptide hormone stimulus
GO:0060042  retina morphogenesis in camera-type eye
GO:0048705  skeletal system morphogenesis
GO:0001756  somitogenesis
GO:0007268  synaptic transmission
GO:0021794  thalamus development
GO:0060535  trachea cartilage morphogenesis
GO:0016055  Wnt receptor signaling pathway
GO:0021874  Wnt receptor signaling pathway in forebrain neuroblast division
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0005901  caveola
GO:0043025  cell soma
GO:0009986  cell surface
GO:0031410  cytoplasmic vesicle
GO:0005769  early endosome
GO:0016021  integral to membrane
GO:0016020  membrane
GO:0005886  plasma membrane
GO:0043235  receptor complex
GO:0045202  synapse

Molecular Function

GO:0034185  apolipoprotein binding
GO:0015026  coreceptor activity
GO:0005109  frizzled binding
GO:0019210  kinase inhibitor activity
GO:0005041  low-density lipoprotein receptor activity
GO:0003674  molecular_function
GO:0042803  protein homodimerization activity
GO:0005102  receptor binding
GO:0019534  toxin transporter activity
GO:0042813  Wnt receptor activity
GO:0017147  Wnt-protein binding