lymphocyte-specific protein tyrosine kinase

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:7.08 cerebellum:6.79 brain stem:7.37 corpus callosum/glia:- pineal gland:- peripheral nerve:7.27 spine:- retina:- eye:7.06 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:9.34 thymus:11.96 bone marrow:7.39 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:7.08 muscle:6.62 esophagus:- stomach:- intestine:7.20 colon:7.22 liver/hepato:- lung:- bladder:- kidney:6.64 pituitary:7.47 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001100709
Gene ID 313050
Unigene ID -
Probe set ID rc_AA800684_at  [RG_U34A]
Ensembl ID ENSRNOG00000009705

Orthologous Gene

Human[4]  NM_001042771, NM_005356
Mouse[3]  NM_001162432, NM_001162433, NM_010693

Chromosomal Region

5q36  [148,707,507  -  148,718,296]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7930951
8104794
8423992
8761480
9116282
9325251
11034334
11477538
12477932
14507881
14652378
14734719
15380937
15712602
16828835
17711737
18178839
19208792
22828953
23715271

Gene Ontology  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0007568  aging
GO:0006915  apoptosis
GO:0050853  B cell receptor signaling pathway
GO:0007166  cell surface receptor linked signal transduction
GO:0006882  cellular zinc ion homeostasis
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0045588  positive regulation of gamma-delta T cell differentiation
GO:0010628  positive regulation of gene expression
GO:0050870  positive regulation of T cell activation
GO:0042523  positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0070474  positive regulation of uterine smooth muscle contraction
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0050856  regulation of T cell receptor signaling pathway
GO:0051209  release of sequestered calcium ion into cytosol
GO:0042493  response to drug
GO:0042542  response to hydrogen peroxide
GO:0009612  response to mechanical stimulus
GO:0010038  response to metal ion
GO:0010043  response to zinc ion
GO:0030217  T cell differentiation

Cellular Component

GO:0030139  endocytic vesicle
GO:0001772  immunological synapse
GO:0045121  membrane raft
GO:0000242  pericentriolar material
GO:0005886  plasma membrane

Molecular Function

GO:0003823  antigen binding
GO:0005524  ATP binding
GO:0051117  ATPase binding
GO:0042609  CD4 receptor binding
GO:0042610  CD8 receptor binding
GO:0001948  glycoprotein binding
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0043548  phosphoinositide 3-kinase binding
GO:0008022  protein C-terminus binding
GO:0032403  protein complex binding
GO:0019901  protein kinase binding
GO:0019903  protein phosphatase binding
GO:0004722  protein serine/threonine phosphatase activity
GO:0004713  protein tyrosine kinase activity
GO:0042169  SH2 domain binding