SMAD family member 4

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:59.80 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:36.90 spine:- retina:- eye:35.50 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:156 thymus:- bone marrow:- adipose:147.20 bone:- skin:235.40
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:189.80 ovary:- testis:- heart:96.90 muscle:- esophagus:- stomach:- intestine:- colon:289.90     liver/hepato:26.60        lung:50.70    bladder:- kidney:- pituitary:118.40 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_019275
Gene ID 50554
Unigene ID Rn.9774
Probe set ID -
Ensembl ID ENSRNOG00000015634

Orthologous Gene

Human[2]  NM_005359
Mouse[3]  NM_008540

Chromosomal Region

18q12.2  [70,432,832  -  70,461,613]

Gene Family (Interpro ID)

IPR003619  MAD homology 1, Dwarfin-type
IPR013019  MAD homology, MH1
IPR001132  SMAD domain, Dwarfin-type
IPR017855  SMAD domain-like
IPR008984  SMAD/FHA domain

Link to Pubmed  (Pubmed ID)

9582123
10331746
10451707
10670756
10706106
10819637
10967130
11332076
11783019
11809701
11920286
12809600
12855402
12894231
12923327
15017584
15036506
15042598
15153551
15344310
15385128
16570350
16859125
16951150
16959941
17347486
17613544
18662538
18684975
18772397
19415695
19506583
20167606
20608350
20926379
21941776
22506032
22507670
22735812

Gene Ontology  (GO ID)

Biological Process

GO:0009952  anterior/posterior pattern formation
GO:0003190  atrioventricular valve formation
GO:0007411  axon guidance
GO:0030509  BMP signaling pathway
GO:0003360  brainstem development
GO:0001658  branching involved in ureteric bud morphogenesis
GO:0003279  cardiac septum development
GO:0008283  cell proliferation
GO:0048589  developmental growth
GO:0060956  endocardial cell differentiation
GO:0007492  endoderm development
GO:0042118  endothelial cell activation
GO:0003198  epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0048859  formation of anatomical boundary
GO:0007369  gastrulation
GO:0001702  gastrulation with mouth forming second
GO:0001701  in utero embryonic development
GO:0001822  kidney development
GO:0007498  mesoderm development
GO:0060548  negative regulation of cell death
GO:0030308  negative regulation of cell growth
GO:0008285  negative regulation of cell proliferation
GO:0042177  negative regulation of protein catabolic process
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0014033  neural crest cell differentiation
GO:0048663  neuron fate commitment
GO:0060021  palate development
GO:0030513  positive regulation of BMP signaling pathway
GO:0003251  positive regulation of cell proliferation involved in heart valve morphogenesis
GO:0010718  positive regulation of epithelial to mesenchymal transition
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0060391  positive regulation of SMAD protein nuclear translocation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0051098  regulation of binding
GO:0042127  regulation of cell proliferation
GO:0051797  regulation of hair follicle development
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0017015  regulation of transforming growth factor beta receptor signaling pathway
GO:0032909  regulation of transforming growth factor-beta2 production
GO:0001666  response to hypoxia
GO:0048733  sebaceous gland development
GO:0007183  SMAD protein complex assembly
GO:0060395  SMAD protein signal transduction
GO:0032525  somite rostral/caudal axis specification
GO:0048729  tissue morphogenesis
GO:0006351  transcription, DNA-dependent
GO:0007179  transforming growth factor beta receptor signaling pathway

Cellular Component

GO:0032444  activin responsive factor complex
GO:0005813  centrosome
GO:0005737  cytoplasm
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0043234  protein complex
GO:0071141  SMAD protein complex
GO:0005667  transcription factor complex

Molecular Function

GO:0003682  chromatin binding
GO:0005518  collagen binding
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0031005  filamin binding
GO:0070411  I-SMAD binding
GO:0042802  identical protein binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0070412  R-SMAD binding
GO:0043565  sequence-specific DNA binding
GO:0046332  SMAD binding
GO:0003700  transcription factor activity
GO:0030616  transforming growth factor beta receptor, common-partner cytoplasmic mediator activity