phosphodiesterase 3A, cGMP inhibited

 jump to detail

Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:6.76 cerebellum:6.68 brain stem:6.77 corpus callosum/glia:- pineal gland:- peripheral nerve:6.53 spine:- retina:- eye:6.86 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:6.86 thymus:6.69 bone marrow:7.04 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:6.88 muscle:6.96 esophagus:- stomach:- intestine:6.61 colon:6.51 liver/hepato:- lung:- bladder:- kidney:6.90 pituitary:6.74 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_017337
Gene ID 50678
Unigene ID Rn.44403
Probe set ID U38179_at  [RG_U34A]
Ensembl ID ENSRNOG00000025042

Orthologous Gene

Human[1]  NM_000921
Mouse[2]  NM_018779

Chromosomal Region

4q44  [178,658,896  -  178,930,417]

Gene Family (Interpro ID)

IPR002073  3'5'-cyclic nucleotide phosphodiesterase
IPR003607  Metal-dependent phosphohydrolase, HD domain

Link to Pubmed  (Pubmed ID)

9631240
9648839
9884079
11673261
11916944
12181425
12466227
12793980
12834273
15867171
17376027
18571642
21224496

Gene Ontology  (GO ID)

Biological Process

GO:0006198  cAMP catabolic process
GO:0019933  cAMP-mediated signaling
GO:0071321  cellular response to cGMP
GO:0019934  cGMP-mediated signaling
GO:0016101  diterpenoid metabolic process
GO:0008152  metabolic process
GO:0043066  negative regulation of apoptosis
GO:0043116  negative regulation of vascular permeability
GO:0001556  oocyte maturation
GO:0060282  positive regulation of oocyte development
GO:0043117  positive regulation of vascular permeability
GO:0040020  regulation of meiosis
GO:0051591  response to cAMP
GO:0042493  response to drug

Cellular Component

GO:0005829  cytosol
GO:0016021  integral to membrane

Molecular Function

GO:0004115  3',5'-cyclic-AMP phosphodiesterase activity
GO:0030552  cAMP binding
GO:0004119  cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
GO:0004112  cyclic-nucleotide phosphodiesterase activity
GO:0046872  metal ion binding