roundabout homolog 1 (Drosophila)

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:155.50 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:36.90 spine:- retina:- eye:35.50 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:39 skin:-
GeneChip cerebrum:5.52 cerebellum:4.96 brain stem:5.39 corpus callosum/glia:- pineal gland:- peripheral nerve:5.20 spine:- retina:- eye:5.56 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:4.81 thymus:4.97 bone marrow:5.13 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:114.10 testis:- heart:38.80 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:63.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:170.70 breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:4.99 muscle:5.06 esophagus:- stomach:- intestine:4.78 colon:4.85 liver/hepato:- lung:- bladder:- kidney:4.99 pituitary:4.74 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_022188
Gene ID 58946
Unigene ID Rn.44468
Probe set ID AF041082_at  [RG_U34A]
Ensembl ID ENSRNOG00000029614

Orthologous Gene

Human[3]  NM_001145845, NM_002941, NM_133631
Mouse[1]  NM_019413, NM_002941, NM_133631

Chromosomal Region

11p11  [11,214,097  -  11,720,646]

Gene Family (Interpro ID)

IPR003961  Fibronectin, type III
IPR008957  Fibronectin, type III-like fold
IPR013106  Immunoglobulin V-set
IPR003596  Immunoglobulin V-set, subgroup
IPR015621  Interleukin-1 receptor
IPR004074  Interleukin-1 receptor, type I/II
IPR009134  Tyrosine-protein kinase, vascular endothelial growth factor receptor (VEGFR), N-terminal

Link to Pubmed  (Pubmed ID)

9458045
10102268
10433822
11404413
11672528
11754167
11779479
15207848
15264215
16254601
16262652
18986510
19783284

Gene Ontology  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0007411  axon guidance
GO:0016199  axon midline choice point recognition
GO:0002042  cell migration involved in sprouting angiogenesis
GO:0007417  central nervous system development
GO:0021836  chemorepulsion involved in postnatal olfactory bulb interneuron migration
GO:0007156  homophilic cell adhesion
GO:0060763  mammary duct terminal end bud growth
GO:0008285  negative regulation of cell proliferation
GO:0070100  negative regulation of chemokine-mediated signaling pathway
GO:0033600  negative regulation of mammary gland epithelial cell proliferation
GO:0050925  negative regulation of negative chemotaxis
GO:0021891  olfactory bulb interneuron development
GO:0050772  positive regulation of axonogenesis
GO:0048814  regulation of dendrite morphogenesis
GO:0021510  spinal cord development

Cellular Component

GO:0030673  axolemma
GO:0030424  axon
GO:0043025  cell soma
GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0016021  integral to membrane
GO:0005886  plasma membrane

Molecular Function

GO:0008046  axon guidance receptor activity
GO:0042802  identical protein binding
GO:0030275  LRR domain binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity