SMAD family member 7

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:122.90 bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:6.29 cerebellum:6.34 brain stem:6.81 corpus callosum/glia:- pineal gland:- peripheral nerve:6.31 spine:- retina:- eye:6.55 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:6.05 thymus:6.18 bone marrow:6.33 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:79.60 prostate:75.90 ovary:- testis:- heart:96.90 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:13.30        lung:101.30    bladder:- kidney:127.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:56.90 breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:6.13 muscle:6.32 esophagus:- stomach:- intestine:6.28 colon:5.96 liver/hepato:- lung:- bladder:- kidney:5.98 pituitary:6.12 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_030858
Gene ID 81516
Unigene ID Rn.29980
Probe set ID AF042499_at  [RG_U34A]
Ensembl ID ENSRNOG00000018359

Orthologous Gene

Human[1]  NM_001190821, NM_001190822, NM_001190823, NM_005904
Mouse[1]  NM_001042660, NM_001190822, NM_001190823, NM_005904

Chromosomal Region

18q12.3  [72,294,803  -  72,323,350]

Gene Family (Interpro ID)

IPR003619  MAD homology 1, Dwarfin-type
IPR013019  MAD homology, MH1
IPR001132  SMAD domain, Dwarfin-type
IPR017855  SMAD domain-like
IPR008984  SMAD/FHA domain

Link to Pubmed  (Pubmed ID)

10656934
11078792
11170839
11181520
11551920
11959632
12023024
12234288
12668667
12809600
12923327
14722617
15661223
15743788
16266486
16278212
16297324
16380081
16931807
17347560
17437042
17541159
17634402
17704451
17723189
17855642
17928287
18095586
18395914
18662538
18762808
18988920
19197123
19349682
20182310
20386537
20943464
21049555
21144460
21429339
21505983
21718693
22338217
23595375
23661026
24211420

Gene Ontology  (GO ID)

Biological Process

GO:0034333  adherens junction assembly
GO:0048844  artery morphogenesis
GO:0034629  cellular protein complex localization
GO:0030514  negative regulation of BMP signaling pathway
GO:0060394  negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0033137  negative regulation of peptidyl-serine phosphorylation
GO:0010801  negative regulation of peptidyl-threonine phosphorylation
GO:0031397  negative regulation of protein ubiquitination
GO:0010944  negative regulation of transcription by competitive promoter binding
GO:0043433  negative regulation of transcription factor activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0030512  negative regulation of transforming growth factor beta receptor signaling pathway
GO:0051444  negative regulation of ubiquitin-protein ligase activity
GO:0060389  pathway-restricted SMAD protein phosphorylation
GO:0022409  positive regulation of cell-cell adhesion
GO:0032436  positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398  positive regulation of protein ubiquitination
GO:0050821  protein stabilization
GO:0032925  regulation of activin receptor signaling pathway
GO:0055117  regulation of cardiac muscle contraction
GO:0017015  regulation of transforming growth factor beta receptor signaling pathway
GO:0034616  response to laminar fluid shear stress
GO:0006351  transcription, DNA-dependent
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0001657  ureteric bud development
GO:0055010  ventricular cardiac muscle tissue morphogenesis
GO:0060412  ventricular septum morphogenesis

Cellular Component

GO:0016342  catenin complex
GO:0005913  cell-cell adherens junction
GO:0005737  cytoplasm
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0005667  transcription factor complex

Molecular Function

GO:0048185  activin binding
GO:0008013  beta-catenin binding
GO:0005518  collagen binding
GO:0044212  DNA regulatory region binding
GO:0070411  I-SMAD binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0003700  transcription factor activity
GO:0030617  transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0034713  type I transforming growth factor beta receptor binding
GO:0031625  ubiquitin protein ligase binding