pyruvate dehydrogenase kinase, isozyme 2

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:95.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:284.30 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:78 thymus:- bone marrow:- adipose:294.40 bone:39 skin:-
GeneChip cerebrum:7.60 cerebellum:8.83 brain stem:7.62 corpus callosum/glia:- pineal gland:- peripheral nerve:7.21 spine:- retina:- eye:7.35 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:6.44 thymus:6.48 bone marrow:6.76 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:79.60 prostate:38 ovary:- testis:1235.20 heart:174.50 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:93.10        lung:101.30    bladder:- kidney:382.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:8.85 muscle:8.41 esophagus:- stomach:- intestine:6.66 colon:6.61 liver/hepato:- lung:- bladder:- kidney:8.68 pituitary:6.84 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_030872
Gene ID 81530
Unigene ID Rn.88597
Probe set ID U10357_at  [RG_U34A]
Ensembl ID ENSRNOG00000004172

Orthologous Gene

Human[2]  NM_001199898, NM_001199899, NM_001199900, NM_002611
Mouse[1]  NM_133667, NM_001199899, NM_001199900, NM_002611

Chromosomal Region

10q31  [83,710,448  -  83,724,973]

Gene Family (Interpro ID)

IPR003594  ATPase-like, ATP-binding domain
IPR004358  Signal transduction histidine kinase-related protein, C-terminal

Link to Pubmed  (Pubmed ID)

7961963
9405293
10698691
11486000
11795479
12435272
12477932
12573248
14966024
15312755
15489334
16216081
16483874
17310282
17544412
18627174
22910903

Gene Ontology  (GO ID)

Biological Process

GO:0031670  cellular response to nutrient
GO:0034614  cellular response to reactive oxygen species
GO:0042593  glucose homeostasis
GO:0006006  glucose metabolic process
GO:0008286  insulin receptor signaling pathway
GO:0018105  peptidyl-serine phosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0010510  regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010565  regulation of cellular ketone metabolic process
GO:0006111  regulation of gluconeogenesis
GO:0010906  regulation of glucose metabolic process
GO:0006885  regulation of pH

Cellular Component

GO:0005737  cytoplasm
GO:0005967  mitochondrial pyruvate dehydrogenase complex
GO:0005739  mitochondrion
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0045254  pyruvate dehydrogenase complex

Molecular Function

GO:0005524  ATP binding
GO:0032403  protein complex binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0004674  protein serine/threonine kinase activity
GO:0004740  pyruvate dehydrogenase (acetyl-transferring) kinase activity