interleukin 12a

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:113.90 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_053390
Gene ID 84405
Unigene ID Rn.207199
Probe set ID -
Ensembl ID ENSRNOG00000009468

Orthologous Gene

Human[1]  NM_000882
Mouse[2]  NM_001159424, NM_008351

Chromosomal Region

2q31  [158,710,261  -  158,717,689]

Gene Family (Interpro ID)

IPR009079  Four-helical cytokine-like, core
IPR004281  Interleukin-12 alpha subunit

Link to Pubmed  (Pubmed ID)

12471147
12697150
14681019
17056578

Gene Ontology  (GO ID)

Biological Process

GO:0007050  cell cycle arrest
GO:0016477  cell migration
GO:0050830  defense response to Gram-positive bacterium
GO:0042832  defense response to protozoan
GO:0006955  immune response
GO:0032700  negative regulation of interleukin-17 production
GO:0048662  negative regulation of smooth muscle cell proliferation
GO:0045785  positive regulation of cell adhesion
GO:0032729  positive regulation of interferon-gamma production
GO:0050671  positive regulation of lymphocyte proliferation
GO:0032816  positive regulation of natural killer cell activation
GO:0045954  positive regulation of natural killer cell mediated cytotoxicity
GO:0002860  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0051135  positive regulation of NK T cell activation
GO:0034393  positive regulation of smooth muscle cell apoptosis
GO:0045582  positive regulation of T cell differentiation
GO:0001916  positive regulation of T cell mediated cytotoxicity
GO:0042102  positive regulation of T cell proliferation
GO:0042520  positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0032496  response to lipopolysaccharide
GO:0010224  response to UV-B
GO:0009615  response to virus

Cellular Component

GO:0005737  cytoplasm
GO:0005615  extracellular space
GO:0043514  interleukin-12 complex

Molecular Function

GO:0005125  cytokine activity
GO:0008083  growth factor activity
GO:0042163  interleukin-12 beta subunit binding
GO:0005143  interleukin-12 receptor binding
GO:0045513  interleukin-27 binding
GO:0046982  protein heterodimerization activity