histone deacetylase 2

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:71.80 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:71.10 artery/aorta:714.30 vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:39 skin:235.40
GeneChip cerebrum:6.59 cerebellum:6.62 brain stem:6.09 corpus callosum/glia:- pineal gland:- peripheral nerve:6.80 spine:- retina:- eye:5.76 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:6.79 thymus:7.77 bone marrow:6.20 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:77.60 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:6.47 muscle:6.87 esophagus:- stomach:- intestine:6.87 colon:6.96 liver/hepato:- lung:- bladder:- kidney:5.75 pituitary:6.94 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_053447
Gene ID 84577
Unigene ID Rn.17971
Probe set ID rc_AA892297_at  [RG_U34A]
Ensembl ID ENSRNOG00000000604

Orthologous Gene

Human[1]  NM_001527
Mouse[1]  NM_008229

Chromosomal Region

20q12  [41,162,093  -  41,186,492]

Gene Family (Interpro ID)

IPR003084  Histone deacetylase
IPR000286  Histone deacetylase superfamily

Link to Pubmed  (Pubmed ID)

8889548
11516394
12403844
12477932
12850547
15051733
15632075
16172792
16670375
17353261
17387270
18212746
18550052
18714364
18754010
18768922
18849323
19139378
19147762
19486889
19553350
21166804
21383775
21465537
21586557
21905265
21987499
22573687
24111946
24218540

Gene Ontology  (GO ID)

Biological Process

GO:0055013  cardiac muscle cell development
GO:0034605  cellular response to heat
GO:0016358  dendrite development
GO:0042733  embryonic digit morphogenesis
GO:0009913  epidermal cell differentiation
GO:0060789  hair follicle placode formation
GO:0021766  hippocampus development
GO:0016575  histone deacetylation
GO:0006344  maintenance of chromatin silencing
GO:0043066  negative regulation of apoptosis
GO:0060044  negative regulation of cardiac muscle cell proliferation
GO:0010977  negative regulation of neuron projection development
GO:0043433  negative regulation of transcription factor activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0030182  neuron differentiation
GO:0042475  odontogenesis of dentine-containing tooth
GO:0008284  positive regulation of cell proliferation
GO:0048714  positive regulation of oligodendrocyte differentiation
GO:0045862  positive regulation of proteolysis
GO:0010870  positive regulation of receptor biosynthetic process
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0006476  protein amino acid deacetylation
GO:0051896  regulation of protein kinase B signaling cascade
GO:0060297  regulation of sarcomere organization
GO:0042220  response to cocaine
GO:0042493  response to drug
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0000785  chromatin
GO:0035098  ESC/E(Z) complex
GO:0000792  heterochromatin
GO:0000790  nuclear chromatin
GO:0005634  nucleus
GO:0016581  NuRD complex
GO:0005657  replication fork
GO:0016580  Sin3 complex
GO:0005667  transcription factor complex
GO:0017053  transcriptional repressor complex

Molecular Function

GO:0003682  chromatin binding
GO:0031490  chromatin DNA binding
GO:0019899  enzyme binding
GO:0031072  heat shock protein binding
GO:0004407  histone deacetylase activity
GO:0032041  NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0046969  NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970  NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0005515  protein binding
GO:0033558  protein deacetylase activity
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding