TEK tyrosine kinase, endothelial

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:203.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:73.70 spine:- retina:- eye:106.60 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:39 skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:38 ovary:- testis:- heart:58.20 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:355.30 thyroid/parathyroid:- adrenal gland:- pancreas:113.80 breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001105737
Gene ID 89804
Unigene ID Rn.91597
Probe set ID -
Ensembl ID ENSRNOG00000008587

Orthologous Gene

Human[2]  NM_000459
Mouse[1]  NM_013690

Chromosomal Region

5q33  [115,047,195  -  115,196,172]

Gene Family (Interpro ID)

IPR000742  EGF-like, type 3
IPR003961  Fibronectin, type III
IPR008957  Fibronectin, type III-like fold
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8217221
8980225
9329972
9660821
10521483
10969034
11397875
11504684
11735002
11822892
11856554
11919509
12174896
12414442
12609966
12665569
12737621
12768384
12814387
13130465
14512515
14530387
14966366
15548727
15714275
15743796
15845622
15899871
15945074
16284088
16389943
16714360
16762501
16917117
16951510
18073453
18285514
18586890
18751736
18929864
18947490
19712575
19786610
20969813
21701128
22577112
22869617
23049737

Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0016337  cell-cell adhesion
GO:0007160  cell-matrix adhesion
GO:0001958  endochondral ossification
GO:0001935  endothelial cell proliferation
GO:0007507  heart development
GO:0060347  heart trabecula formation
GO:0030097  hemopoiesis
GO:0016525  negative regulation of angiogenesis
GO:0043066  negative regulation of apoptosis
GO:0031100  organ regeneration
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0045766  positive regulation of angiogenesis
GO:0045785  positive regulation of cell adhesion
GO:0010595  positive regulation of endothelial cell migration
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0051894  positive regulation of focal adhesion formation
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0010740  positive regulation of protein kinase cascade
GO:0046777  protein amino acid autophosphorylation
GO:0051259  protein oligomerization
GO:0045765  regulation of angiogenesis
GO:0030334  regulation of cell migration
GO:0032878  regulation of establishment or maintenance of cell polarity
GO:0051591  response to cAMP
GO:0043627  response to estrogen stimulus
GO:0001666  response to hypoxia
GO:0010033  response to organic substance
GO:0043434  response to peptide hormone stimulus
GO:0032526  response to retinoic acid
GO:0002040  sprouting angiogenesis
GO:0034446  substrate adhesion-dependent cell spreading
GO:0048014  Tie receptor signaling pathway
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway
GO:0001570  vasculogenesis

Cellular Component

GO:0005884  actin filament
GO:0016324  apical plasma membrane
GO:0009925  basal plasma membrane
GO:0016323  basolateral plasma membrane
GO:0009986  cell surface
GO:0005911  cell-cell junction
GO:0005575  cellular_component
GO:0005887  integral to plasma membrane
GO:0045121  membrane raft
GO:0005902  microvillus
GO:0001725  stress fiber

Molecular Function

GO:0005524  ATP binding
GO:0019838  growth factor binding
GO:0004713  protein tyrosine kinase activity
GO:0004872  receptor activity
GO:0004716  receptor signaling protein tyrosine kinase activity
GO:0004714  transmembrane receptor protein tyrosine kinase activity